Evidence map›Paper›PMID 29395615›Full record

ReviewHearing research2018

Subcortical pathways: Towards a better understanding of auditory disorders.

Richard A Felix, Boris Gourévitch, Christine V Portfors

Open access · greenAbstract readReview
In one paragraph

Review in Hearing research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Richard A FelixSchool of Biological Sciences and Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA, USA.
Boris GourévitchUnité de Génétique et Physiologie de l'Audition, UMRS 1120 INSERM, Institut Pasteur, Université Pierre et Marie Curie, F-75015, Paris, France; CNRS, France.
Christine V PortforsSchool of Biological Sciences and Integrative Physiology and Neuroscience, Washington State University, Vancouver, WA, USA. Electronic address: portfors@wsu.edu.
Washington State University Vancouver · USCentre National de la Recherche Scientifique · FR

Funding

Neuromodulation in the auditory systemR01DC013102 · NIDCD · WASHINGTON STATE UNIVERSITY · PI PERKEL, DAVID J, PORTFORS, CHRISTINE · 2014 to 2018
$1.8M
NIDCD NIH HHS R01 DC013102
6 · The paper itself

Abstract

Hearing loss is a significant problem that affects at least 15% of the population. This percentage, however, is likely significantly higher because of a variety of auditory disorders that are not identifiable through traditional tests of peripheral hearing ability. In these disorders, individuals have difficulty understanding speech, particularly in noisy environments, even though the sounds are loud enough to hear. The underlying mechanisms leading to such deficits are not well understood. To enable the development of suitable treatments to alleviate or prevent such disorders, the affected processing pathways must be identified. Historically, mechanisms underlying speech processing have been thought to be a property of the auditory cortex and thus the study of auditory disorders has largely focused on cortical impairments and/or cognitive processes. As we review here, however, there is strong evidence to suggest that, in fact, deficits in subcortical pathways play a significant role in auditory disorders. In this review, we highlight the role of the auditory brainstem and midbrain in processing complex sounds and discuss how deficits in these regions may contribute to auditory dysfunction. We discuss current research with animal models of human hearing and then consider human studies that implicate impairments in subcortical processing that may contribute to auditory disorders.

Indexed as

Auditory PerceptionAcoustic StimulationAnimalsAuditory CortexAuditory PathwaysAuditory Perceptual DisordersCuesHearingHumansTime PerceptionInferior colliculusTemporal processingVocalization selectivity

Identifiers

PMID29395615
PMCPMC5911198
OpenAlexW2793123547

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.