Evidence map›Paper›PMID 29395231›Full record

ArticleJournal of biomechanics2018

Original article submission: Platelet stress accumulation analysis to predict thrombogenicity of an artificial kidney.

Amanda K W Buck, Steven G Goebel, Mark S Goodin, Nathan J Wright, Joseph J Groszek, Jarrett Moyer, Sukhveer Singh, Danny Bluestein, William H Fissell, Shuvo Roy

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of biomechanics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Mathematical and Computational Modeling of Device-Induced Thrombosis.Current opinion in biomedical engineering · 2021
    Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 1 country.

Amanda K W BuckDepartment of Radiology and Radiological Sciences, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN, USA.
Steven G GoebelSimuTech Group, Rochester, NY, USA.
Mark S GoodinSimuTech Group, Rochester, NY, USA.
Nathan J WrightDepartment of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA.
Joseph J GroszekNephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
Jarrett MoyerDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Sukhveer SinghDepartment of Surgery, University of California San Francisco, San Francisco, CA, USA.
Danny BluesteinDepartment of Biomedical Engineering, Stony Brook University, Stony Brook, NY, USA.
William H FissellNephrology and Hypertension, Vanderbilt University Medical Center, Nashville, TN, USA.
Shuvo RoyDepartment of Bioengineering & Therapeutic Sciences, University of California San Francisco, San Francisco, CA, USA. Electronic address: shuvo.roy@ucsf.edu.
University of California, San Francisco · USVanderbilt University Medical Center · USStony Brook University · USVanderbilt University · US

Funding

Building an Implantable Artificial KidneyU01EB021214 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI FISSELL, WILLIAM H, ROY, SHUVO · 2015 to 2018
$6.0M
RESEARCH TRAINING IN GASTROINTESTINAL SURGERYT32DK007573 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HARRIS, HOBART WHITAKER · 1988 to 2019
$3.0M
Biocompatibility of Implantable Renal Replacement DevicesR01EB014315 · NIBIB · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ROY, SHUVO · 2012 to 2015
$2.3M
NIBIB NIH HHS R01 EB014315NIBIB NIH HHS U01 EB021214NIDDK NIH HHS T32 DK007573
6 · The paper itself

Abstract

An implantable artificial kidney using a hemofilter constructed from an array of silicon membranes to provide ultrafiltration requires a suitable blood flow path to ensure stable operation in vivo. Two types of flow paths distributing blood to the array of membranes were evaluated: parallel and serpentine. Computational fluid dynamics (CFD) simulations were used to guide the development of the blood flow paths. Pressure data from animal tests were used to obtain pulsatile flow conditions imposed in the transient simulations. A key consideration for stable operation in vivo is limiting platelet stress accumulation to avoid platelet activation and thrombus formation. Platelet stress exposure was evaluated by CFD particle tracking methods through the devices to provide distributions of platelet stress accumulation. The distributions of stress accumulation over the duration of a platelet lifetime for each device revealed that stress accumulation for the serpentine flow path exceeded levels expected to cause platelet activation while the accumulated stress for the parallel flow path was below expected activation levels.

Indexed as

Computer SimulationKidneys, ArtificialStress, PhysiologicalAnimalsBlood PlateletsHydrodynamicsModels, CardiovascularPlatelet ActivationPressurePulsatile FlowThrombosisArtificial kidneyHemodynamicsPlatelet stress accumulationThrombogenicity

Identifiers

PMID29395231
PMCPMC5809289
OpenAlexW2783818025

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.