Trial reportAddictive behaviors2018
Real-time assessment of alcohol craving and naltrexone treatment responsiveness in a randomized clinical trial.
Trial report in Addictive behaviors, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Drug Treatment of Trichotillomania (Hair-Pulling Disorder), Excoriation (Skin-picking) Disorder, and Nail-biting (Onychophagia).Current neuropharmacology · 2019Pooled it
- A day-by-day prospective analysis of stress, craving and risk of next day alcohol intake during alcohol use disorder treatment.Drug and alcohol dependence · 2019Trial
- Prazosin-Related Reductions in Daily Craving Mediate Treatment-Related Daily Alcohol Use Outcomes in Alcohol Use Disorder.Biological psychiatry global open science · 2026Article
- The Development of a Patient-Centered Digital Health Care Technology for Young Adults in Opioid Use Disorder Treatment: Qualitative Study.JMIR formative research · 2025Article
- Subjective responses to simultaneous alcohol and cannabis use relative to alcohol-only use and cannabis-only use: An ecological momentary assessment investigation.Alcohol, clinical & experimental research · 2025Article
- Melatonin Reduces Alcohol Drinking in Rats with Disrupted Function of the Serotonergic System.Journal of personalized medicine · 2022Article
- Translational approach to understanding momentary factors associated with alcohol consumption.British journal of pharmacology · 2020Review
- Underlying Susceptibility to Eating Disorders and Drug Abuse: Genetic and Pharmacological Aspects of Dopamine D4 Receptors.Nutrients · 2020Review
- OPRM1 Moderates Daily Associations of Naltrexone Adherence With Alcohol Consumption: Preliminary Evidence From a Mobile Health Trial.Alcoholism, clinical and experimental research · 2020Article
- The effect of SMS behavior change techniques on event-level desire to get drunk in young adults.Psychology of addictive behaviors : journal of the Society of Psychologists in Addictive Behaviors · 2020Article
- Assessment of Alcohol Use in the Natural Environment.Alcoholism, clinical and experimental research · 2019Review
- Risk-Taking Propensity, Affect, and Alcohol Craving in Adolescents' Daily Lives.Substance use & misuse · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
introductionThis secondary data analysis examined whether and how the dopamine receptor D
methodsParticipants (M
resultsModerated-mediation multilevel structural equation models showed that craving during non-drinking moments mediated the treatment effect of naltrexone on heavy drinking but only among carriers of the DRD4-L allele. The same pattern of associations was not shown when evaluating craving while participants were consuming alcoholic beverages.
conclusionsFindings provide the first in vivo evidence that, among carriers of the DRD4-L allele, naltrexone blunts craving in real-world settings, and this effect in turn reduces the likelihood of heavy drinking. This work highlights the utility of EMA methods for elucidating how treatments work and further demonstrates the importance of genetic factors for understanding individual differences in pharmacotherapy responsiveness.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.