ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2018
Effects of Coexisting Asthma and Obstructive Sleep Apnea on Sleep Architecture, Oxygen Saturation, and Systemic Inflammation in Women.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05950646 (Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery), which is not on this map. Cited by 18 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effect of Mini-dose Dexmedetomidine-Esketamine Infusion on Sleep Quality in Older Patients Undergoing Knee or Hip Replacement Surgery: A Multicenter Randomized Controlled Trial
Who cites it
18 citing papers in PubMed, 5 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Association of obstructive sleep apnea risk with allergic asthma: A systematic review and meta-analysis.Medicine · 2025Pooled it
- The relationship between obstructive sleep apnea and asthma severity and vice versa: a systematic review and meta-analysis.European journal of medical research · 2023Pooled it
- Comparing the effects of supplemental oxygen therapy and continuous positive airway pressure on patients with obstructive sleep apnea: a meta-analysis of randomized controlled trials.Sleep & breathing = Schlaf & Atmung · 2021Pooled it
- Association between tumor necrosis factor alpha and obstructive sleep apnea in adults: a meta-analysis update.BMC pulmonary medicine · 2020Pooled it
- Evaluation of Serum and Plasma Interleukin-6 Levels in Obstructive Sleep Apnea Syndrome: A Meta-Analysis and Meta-Regression.Frontiers in immunology · 2020Pooled it
- Association of obstructive airway disease with COMISA: findings from the Turkish sleep apnea database (TURKAPNE) cohort.Sleep & breathing = Schlaf & Atmung · 2026Observational
- Asthma and Obstructive Sleep Apnea Overlap Syndrome Identifies a Phenotype of Sleep Instability and Increased Psychological Burden.Life (Basel, Switzerland) · 2026Article
- Clinical and Sleep Characteristics and the Effect of CPAP Treatment on Obese Patients with Obstructive Sleep Apnea and Asthma-A Retrospective Study.Healthcare (Basel, Switzerland) · 2025Article
- Genetic overlap and immunological pathways in asthma-obstructive sleep apnea coexistence.Sleep & breathing = Schlaf & Atmung · 2025Article
- Do nocturnal asthma attacks influence sleep parameters and inflammatory markers? A cross-sectional population-based study.Sleep & breathing = Schlaf & Atmung · 2024Article
- Revisiting Asthma Obstructive Sleep Apnea Overlap: Current Knowledge and Future Needs.Journal of clinical medicine · 2023Review
- Asthma and asthma-related comorbidity: effects on nocturnal oxygen saturation.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- The Association between Asthma and OSA in Children.Children (Basel, Switzerland) · 2022Article
- The negative health effects of having a combination of snoring and insomnia.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Τhe Co-Existence of Obstructive Sleep Apnea and Bronchial Asthma: Revelation of a New Asthma Phenotype?Journal of clinical medicine · 2019Review
- Snoring and nocturnal reflux: association with lung function decline and respiratory symptoms.ERJ open research · 2019Article
- Obstructive sleep apnea and comorbidities: a dangerous liaison.Multidisciplinary respiratory medicine · 2019Review
- Current opinions for the management of asthma associated with ear, nose and throat comorbidities.European respiratory review : an official journal of the European Respiratory Society · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
STUDY
objectivesBoth asthma and obstructive sleep apnea (OSA) are strongly associated with poor sleep. Asthma and OSA also have several features in common, including airway obstruction, systemic inflammation, and an association with obesity. The aim was to analyze the effect of asthma, OSA, and the combination of asthma and OSA on objectively measured sleep quality and systemic inflammation.
methodsSleep and health in women is an ongoing community-based study in Uppsala, Sweden. Three hundred eighty-four women ages 20 to 70 years underwent overnight polysomnography and completed questionnaires on airway diseases and sleep complaints. C-reactive protein (CRP), interleukin 6 (IL-6), and tumor necrosis factor α were analyzed.
resultsThe group with both asthma and OSA had higher CRP, higher IL-6, a longer sleeping time in stage N1 sleep and stage N2 sleep, and less time in stage R sleep than the control group with no asthma or OSA. The group with both asthma and OSA had lower mean oxygen saturation (93.4% versus 94.7%,
conclusionsOur data indicate that coexisting asthma and OSA are associated with poorer sleep quality and more profound nocturnal hypoxemia than either of the conditions alone. The results are similar to earlier findings related to OSA and chronic obstructive pulmonary disease, but they have not previously been described for asthma.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.