Evidence map›Paper›PMID 29394908›Full record

ArticleTrials2018

Intermittent fasting, energy balance and associated health outcomes in adults: study protocol for a randomised controlled trial.

Iain Templeman, Dylan Thompson, Javier Gonzalez, Jean-Philippe Walhin, Sue Reeves, Peter J Rogers, Jeffrey M Brunstrom, Leonidas G Karagounis, Kostas Tsintzas, James A Betts

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02498002 (Impacts of Intermittent Fasting in Adults on Energy Balance, Body Composition, Postprandial Hormone Profiles and Gene Expression in Adipose Tissue), which is not on this map. Cited by 9 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 5 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02498002 nacompletednot on this map

Impacts of Intermittent Fasting in Adults on Energy Balance, Body Composition, Postprandial Hormone Profiles and Gene Expression in Adipose Tissue

TypeinterventionalSponsorUniversity of BathRan2015 to 2018Enrolled54ConditionsObesity, Type 2 DiabetesArmsPhysical Activity Monitoring (Actiheart), Energy Intake Monitoring, Body Weight Monitoring, Intravenous Cannulation, Adipose Tissue Biopsy
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 5 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
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  5. Pooled it
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 1 country.

Iain TemplemanDepartment for Health, University of Bath, Bath, BA2 7AY, UK. i.s.templeman@bath.ac.uk.ORCID http://orcid.org/0000-0002-1684-5943
Dylan ThompsonDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
Javier GonzalezDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
Jean-Philippe WalhinDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
Sue ReevesDepartment of Life Sciences, University of Roehampton, London, SW15 4JD, UK.
Peter J RogersSchool of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK.
Jeffrey M BrunstromSchool of Experimental Psychology, University of Bristol, Bristol, BS8 1TU, UK.
Leonidas G KaragounisFaculty of Sport and Health Sciences, University of St Mark and St John, Plymouth, PL6 8BH, UK.
Kostas TsintzasSchool of Life Sciences, University of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
James A BettsDepartment for Health, University of Bath, Bath, BA2 7AY, UK.
University of Bath · GBUniversity of Bristol · GBPlymouth Marjon University · GBUniversity of Nottingham · GBUniversity of Roehampton · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrior studies have shown that intermittent fasting is capable of producing improvements in body weight and fasted health markers. However, the extent to which intermittent fasting incurs compensatory changes in the components of energy balance and its impact on postprandial metabolism are yet to be ascertained.

methodsA total of 30-36 lean participants and 30-36 overweight/obese participants will be recruited to provide two separate study groups who will undergo the same protocol. Following an initial assessment of basic anthropometry and key health markers, measurements of habitual energy intake (weighed food and fluid intake) and physical activity energy expenditure (combined heart rate and accelerometry) will be obtained over 4 weeks under conditions of energy balance. Participants will then be randomly allocated to one of three experimental conditions for 20 days, namely (1) daily calorie restriction (reduce habitual daily energy intake by 25%), (2) intermittent fasting with calorie restriction (alternate between 24-hour periods of fasting and feeding to 150% of habitual daily energy intake), (3) intermittent fasting without calorie restriction (alternate between 24-hour periods of fasting and feeding to 200% of habitual daily energy intake). In addition to continued monitoring of energy intake and physical activity during the intervention, participants will report for laboratory-based assessments of various metabolic parameters both before and after the intervention. Specifically, fasting and postprandial measurements of resting metabolic rate, substrate oxidation, appetite, food preference, and plasma concentrations of key metabolites and hormones will be made, in addition to subcutaneous abdominal adipose tissue biopsies in the fasted state and an assessment of body composition via dual-energy x-ray absorptiometry. DISCUSSION: Comparing observed changes in these measures across the three intervention arms in each group will establish the impact of intermittent fasting on postprandial metabolism and the components of energy balance in both lean and overweight/obese populations. Furthermore, this will be benchmarked against current nutritional interventions for weight management and the relative contributions of negative energy balance and fasting-dependent mechanisms in inducing any observed effects will be elucidated.

trial registrationTrial retrospectively registered at clinicaltrials.gov under reference number NCT02498002 (version: IMF-02, date: July 6, 2015).

Indexed as

Caloric RestrictionEnergy MetabolismFastingWeight LossAdolescentAdultAgedBody CompositionEnglandFemaleHumansMaleMiddle AgedNutritional StatusObesityPostprandial PeriodBody compositionCalorie restrictionEnergy balanceIntermittent fastingMetabolismObesityPhysical activityPostprandial

Identifiers

PMID29394908
PMCPMC5797418
OpenAlexW2786596659

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.