ArticleBMC medical genomics2018
Methylation of the genes ROD1, NLRC5, and HKR1 is associated with aging in Hainan centenarians.
Article in BMC medical genomics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Epigenome-wide meta-analysis identifies DNA methylation biomarkers associated with diabetic kidney disease.Nature communications · 2022Pooled it
- An epigenome-wide association study of early-onset major depression in monozygotic twins.Translational psychiatry · 2020Pooled it
- Novel RNA transcript signatures for accurate age prediction using RNA profiling.International journal of legal medicine · 2026Article
- Hainan Longevity Model, Senile Degeneration, Cognitive Disability and Healthy Longevity.Aging medicine (Milton (N.S.W)) · 2026Review
- Prognosis, immunological features and potential mechanisms of HKR1 in prostate cancer via single-cell and bulk RNA-sequencing.BMC cancer · 2025Article
- Advancing Personalized Medicine in Alzheimer's Disease: Liquid Biopsy Epigenomics UnveilInternational journal of molecular sciences · 2025Article
- Changes in Whole Blood Polyamine Levels and Their Background in Age-Related Diseases and Healthy Longevity.Biomedicines · 2023Review
- Hypermethylation in H3K9me3 regions characterizes the centenarian methylomes in healthy aging.National science review · 2023Article
- Parity is associated with long-term differences in DNA methylation at genes related to neural plasticity in multiple sclerosis.Clinical epigenetics · 2023Article
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- Article
- Review
- Identification of Immune Cells and Key Genes associated with Alzheimer's Disease.International journal of medical sciences · 2022Article
- Epigenetics meets proteomics in an epigenome-wide association study with circulating blood plasma protein traits.Nature communications · 2020Article
- Extracellular Spermine Activates DNA Methyltransferase 3A and 3B.International journal of molecular sciences · 2019Article
- Emerging Roles for NLRC5 in Immune Diseases.Frontiers in pharmacology · 2019Review
- Polyamine Metabolism and Gene Methylation in Conjunction with One-Carbon Metabolism.International journal of molecular sciences · 2018Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman aging is a hot topic in biology, and it has been associated with DNA methylation changes at specific genomic sites. We aimed to study the changes of DNA methylation at a single-CpG-site resolution using peripheral blood samples from centenarians.
methodsUsing Illumina 450 K Methylation BeadChip microarray assays, we carried out a pool-based, epigenome-wide investigation of DNA methylation of blood samples from 12 centenarians and 12 healthy controls. Differentially methylated cytosine-phosphate-guanosine (CpG) sites were selected for further pyrosequencing analysis of blood samples from 30 centenarians and 30 healthy controls.
resultWe identified a total of 31 high-confidence CpG sites with differential methylation profiles between the groups: 9 (29%) were hypermethylated and 22 (71%) were hypomethylated in centenarians. It was also found that hypermethylation of HKR1 and hypomethylation of ROD1 and NLRC5 genes strongly correlated with age in centenarians.
conclusionOur results indicate that the methylation profile combination of HKR1, ROD1, and NLRC5 could be a promising biomarker for aging in Hainan centenarians.
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Registered trials
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