ArticleBMC evolutionary biology2018
Wnt signaling and polarity in freshwater sponges.
Article in BMC evolutionary biology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- Wnt signaling patterns a central-peripheral body axis in the early-diverging metazoan Trichoplax adhaerens.Molecular biology and evolution · 2026Article
- Article
- Telocytes deliver essential Wnts directly to murine intestinal stem cells via synapse-like contacts.Developmental cell · 2025Article
- Planar cell polarity coordination in a cnidarian embryo provides clues to animal body axis evolution.eLife · 2025Article
- Article
- ATP and glutamate coordinate contractions in the freshwater sponge Ephydatia muelleri.The Journal of experimental biology · 2025Article
- The chromosomal genome sequence of the fragile freshwater sponge,Wellcome open research · 2025Article
- The Buds of Oscarella lobularis (Porifera, Homoscleromorpha): A New Convenient Model for Sponge Cell and Evolutionary Developmental Biology.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024Article
- Developmental bisphenol S toxicity in two freshwater animal models.Environmental toxicology and pharmacology · 2023Article
- The compact genome of the sponge Oopsacas minuta (Hexactinellida) is lacking key metazoan core genes.BMC biology · 2023Article
- Transfection of Sponge Cells and Intracellular Localization of Cancer-Related MYC, RRAS2, and DRG1 Proteins.Marine drugs · 2023Article
- A pan-metazoan concept for adult stem cells: the wobbling Penrose landscape.Biological reviews of the Cambridge Philosophical Society · 2022Article
- Extensive loss of Wnt genes in Tardigrada.BMC ecology and evolution · 2021Article
- Comparative Proteome Analysis Indicates The Divergence between The Head and Tail Regeneration in Planarian.Cell journal · 2021Article
- Evolution of mechanisms controlling epithelial morphogenesis across animals: new insights from dissociation-reaggregation experiments in the sponge Oscarella lobularis.BMC ecology and evolution · 2021Article
- Conservative and Atypical Ferritins of Sponges.International journal of molecular sciences · 2021Article
- The developmental biology ofScience advances · 2021Article
- Article
- The origin of animals: an ancestral reconstruction of the unicellular-to-multicellular transition.Open biology · 2021Review
- Article
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe Wnt signaling pathway is uniquely metazoan and used in many processes during development, including the formation of polarity and body axes. In sponges, one of the earliest diverging animal groups, Wnt pathway genes have diverse expression patterns in different groups including along the anterior-posterior axis of two sponge larvae, and in the osculum and ostia of others. We studied the function of Wnt signaling and body polarity formation through expression, knockdown, and larval manipulation in several freshwater sponge species.
resultsSponge Wnts fall into sponge-specific and sponge-class specific subfamilies of Wnt proteins. Notably Wnt genes were not found in transcriptomes of the glass sponge Aphrocallistes vastus. Wnt and its signaling genes were expressed in archaeocytes of the mesohyl throughout developing freshwater sponges. Osculum formation was enhanced by GSK3 knockdown, and Wnt antagonists inhibited both osculum development and regeneration. Using dye tracking we found that the posterior poles of freshwater sponge larvae give rise to tissue that will form the osculum following metamorphosis.
conclusionsTogether the data indicate that while components of canonical Wnt signaling may be used in development and maintenance of osculum tissue, it is likely that Wnt signaling itself occurs between individual cells rather than whole tissues or structures in freshwater sponges.
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