ArticlePloS one2018
Impaired retinal microcirculation in patients with Alzheimer's disease.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05475158 (Comparison of Optical Coherence Tomography Angiographic Factors of Macula and Optic Disc in Patients With or Without Amyloid Pathology), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparison of Optical Coherence Tomography Angiographic Factors of Macula and Optic Disc in Patients With or Without Amyloid Pathology: A Prospective Study
Who cites it
37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- Retinal Microvascular Changes in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review, Meta-Analysis, and Meta-Regression.Frontiers in aging neuroscience · 2022Pooled it
- Optical Coherence Tomography in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis.Frontiers in neurology · 2020Pooled it
- Spore powder of Ganoderma lucidum for the treatment of Alzheimer disease: A pilot study.Medicine · 2018Trial
- Reduced Retinal Perfusion With Preserved Microvascular Network Density in Early Alzheimer's Disease: A Multimodal Imaging Study.Translational vision science & technology · 2026Article
- Independent Conjunctival and Retinal Microcirculatory Improvements Following OcufolinCurrent eye research · 2026Article
- Early Detection of Dementia Through Spectralis Optical Coherence Tomography in a Taiwanese Cohort.Diagnostics (Basel, Switzerland) · 2026Article
- A multimodal machine-learning diagnostic model for Alzheimer's disease: integrating OCTA-derived retinal microvascular features and clinical variables.Frontiers in aging neuroscience · 2026Article
- Retinal neurovascular and mitochondrial function signatures related to cognition improvement following yoga exercise in older adults.PloS one · 2026Article
- Retinal Neurovascular Signatures in Parkinson's Disease.Investigative ophthalmology & visual science · 2025Article
- Exploring Retinal Neurodegeneration in Alzheimer's Disease: A Molecular and Cellular Perspective.Neurotoxicity research · 2025Review
- Retinal microvascular and microcirculatory responses related to cognition improvement following yoga training in patients with Parkinson's disease.Clinical parkinsonism & related disorders · 2025Article
- Retinal perfusion is linked to cognition and brain MRI biomarkers in Black Americans.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Article
- Retinal thickness and vascular parameters using optical coherence tomography in Alzheimer's disease: a meta-analysis.Neural regeneration research · 2023Article
- The Association ofJournal of clinical medicine · 2023Article
- Comparison of Retinal Structural and Neurovascular Changes between Patients with and without Amyloid Pathology.Journal of clinical medicine · 2023Article
- Retinal Microvascular Dysfunction Occurs Early and Similarly in Mild Alzheimer's Disease and Primary-Open Angle Glaucoma Patients.Journal of clinical medicine · 2022Article
- Article
- Retinal Vascular Study Using OCTA in Subjects at High Genetic Risk of Developing Alzheimer's Disease and Cardiovascular Risk Factors.Journal of clinical medicine · 2022Article
- Imaging of the skin microvascularization using spatially depolarized dynamic speckle.Journal of biomedical optics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
Abstract
The goal of this study was to determine the retinal blood flow rate (BFR) and blood flow velocity (BFV) of pre-capillary arterioles and post-capillary venules in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Forty patients (20 AD and 20 MCI) and 21 cognitively normal (CN) controls with a similar age range (± 5 yrs) were recruited. A retinal function imager (RFI) was used to measure BFRs and BFVs of arterioles and venules in the macular region. The thickness of the ganglion cell-inner plexiform layer (GCIPL) was measured using Zeiss Cirrus optical coherence tomography. Macular BFRs in AD group were 2.64 ± 0.20 nl/s (mean ± standard deviation) in arterioles and 2.23 ± 0.19 nl/s in venules, which were significantly lower than in MCI and CN groups (P < 0.05). In addition, BFRs in MCI were lower than in CN in both arterioles and venules (P < 0.05). The BFV of the arterioles was 3.20 ± 1.07 mm/s in AD patients, which was significantly lower than in CN controls (3.91 ± 0.77 mm/s, P = 0.01). The thicknesses of GCIPL in patients with AD and MCI were significantly lower than in CN controls (P < 0.05). Neither BFV nor BFR in arterioles and venules was related to age, GCIPL thickness, mini mental state examination (MMSE) score and disease duration in patients with AD and MCI (P > 0.05). The lower BFR in both arterioles and venules in AD and MCI patients together with the loss of GCIPL were evident, indicating the impairment of the two components in the neurovascular-hemodynamic system, which may play a role in disease progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.