Evidence map›Paper›PMID 29394251›Full record

ArticlePloS one2018

Examining the short-term anxiolytic and antidepressant effect of Floatation-REST.

Justin S Feinstein, Sahib S Khalsa, Hung-Wen Yeh, Colleen Wohlrab, W Kyle Simmons, Murray B Stein, Martin P Paulus

4 registry-linked trialsAbstract read
In one paragraph

Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03051074 nacompletednot on this map

Examining the Effects of Reduced Environmental Stimulation on Anxiety

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2016 to 2019Enrolled60ConditionsGeneralized Anxiety Disorder, Agoraphobia, Panic Disorder, PostTraumatic Stress DisorderArmsFloating, Comparison
NCT04368689 naactive not recruitingnot on this mapstarted 2021, after this paper: background citation

The Feasibility and Examination of the Effects of Floatation-based Reduced Environmental Stimulation Therapy (REST) on a Community Sample With Posttraumatic Stress Disorder (PTSD)

TypeinterventionalSponsorMedical College of WisconsinRan2021 to 2027Enrolled30ConditionsPost-Traumatic Stress DisordersArmsFloatation-based reduced environmental stimulation therapy
NCT05977894 enrolling by invitationnot on this mapstarted 2023, after this paper: background citation

Wellbeing Monitoring During Sequential Reduced Environmental Stimulation-Floatation

TypeobservationalSponsorMercy Health OhioRan2023 to 2026Enrolled50ConditionsBurnout, Professional, Negative Affect, Positive Affect, WellbeingArmsReduced Environmental Stimulation Therapy
NCT06332963 narecruitingnot on this mapstarted 2024, after this paper: background citation

Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa

TypeinterventionalSponsorLaureate Institute for Brain Research, Inc.Ran2024 to 2028Enrolled102ConditionsAnorexia Nervosa, Body Image Disturbance, InteroceptionArmsFloatation-REST, IFT, EFT
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Trial
  5. Trial
  6. Trial
  7. Trial
  8. Review
  9. Article
  10. The micro-phenomenology of Floatation-REST.BMC complementary medicine and therapies · 2026
    Article
  11. Article
  12. Review
  13. Observational
  14. Sensing the Self: The Role of the Insula and Interoception in Body Image.Current topics in behavioral neurosciences · 2025
    Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Justin S FeinsteinLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.ORCID 0000-0003-0802-8406
Sahib S KhalsaLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.
Hung-Wen YehLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.
Colleen WohlrabLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.
W Kyle SimmonsLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.
Murray B SteinUniversity of California San Diego, La Jolla, California, United States of America.
Martin P PaulusLaureate Institute for Brain Research, Tulsa, Oklahoma, United States of America.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Floatation-REST (Reduced Environmental Stimulation Therapy) reduces sensory input to the nervous system through the act of floating supine in a pool of water saturated with Epsom salt. The float experience is calibrated so that sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational and proprioceptive channels are minimized, as is most movement and speech. This open-label study aimed to examine whether Floatation-REST would attenuate symptoms of anxiety, stress, and depression in a clinical sample. Fifty participants were recruited across a spectrum of anxiety and stress-related disorders (posttraumatic stress, generalized anxiety, panic, agoraphobia, and social anxiety), most (n = 46) with comorbid unipolar depression. Measures of self-reported affect were collected immediately before and after a 1-hour float session, with the primary outcome measure being the pre- to post-float change score on the Spielberger State Anxiety Inventory. Irrespective of diagnosis, Floatation-REST substantially reduced state anxiety (estimated Cohen's d > 2). Moreover, participants reported significant reductions in stress, muscle tension, pain, depression and negative affect, accompanied by a significant improvement in mood characterized by increases in serenity, relaxation, happiness and overall well-being (p < .0001 for all variables). In reference to a group of 30 non-anxious participants, the effects were found to be more robust in the anxious sample and approaching non-anxious levels during the post-float period. Further analysis revealed that the most severely anxious participants reported the largest effects. Overall, the procedure was well-tolerated, with no major safety concerns stemming from this single session. The findings from this initial study need to be replicated in larger controlled trials, but suggest that Floatation-REST may be a promising technique for transiently reducing the suffering in those with anxiety and depression.

trial registrationClinicalTrials.gov NCT03051074.

Indexed as

Sensory DeprivationAdultAnxietyDepressionFemaleHumansMale

Identifiers

PMID29394251
PMCPMC5796691

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.