ArticlePloS one2018
Examining the short-term anxiolytic and antidepressant effect of Floatation-REST.
Article in PloS one, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 30 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Examining the Effects of Reduced Environmental Stimulation on Anxiety
The Feasibility and Examination of the Effects of Floatation-based Reduced Environmental Stimulation Therapy (REST) on a Community Sample With Posttraumatic Stress Disorder (PTSD)
Wellbeing Monitoring During Sequential Reduced Environmental Stimulation-Floatation
Interoceptive Mechanisms of Body Image Disturbance in Anorexia Nervosa
Who cites it
30 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- A systematic review of flotation-restricted environmental stimulation therapy (REST).BMC complementary medicine and therapies · 2025Pooled it
- Fears Worth Testing Out: A Systematic Review of the Neural Mechanisms of Treatment Outcome for Anxiety-Related Disorders.Current topics in behavioral neurosciences · 2025Pooled it
- The neural correlates of well-being: A systematic review of the human neuroimaging and neuropsychological literature.Cognitive, affective & behavioral neuroscience · 2019Pooled it
- Reversible modulation of a deep white matter surgical target for depression with low-intensity focused ultrasound.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Trial
- Induction of altered states of consciousness during Floatation-REST is associated with the dissolution of body boundaries and the distortion of subjective time.Scientific reports · 2024Trial
- A randomized controlled safety and feasibility trial of floatation-REST in anxious and depressed individuals.PloS one · 2024Trial
- Flotation Restricted Environmental Stimulation Therapy for Chronic Pain: A Randomized Clinical Trial.JAMA network open · 2021Trial
- Cumulative trauma, neural circuits, and burnout: an integrative model of healthcare worker post-traumatic stress syndromes.European journal of psychotraumatology · 2026Review
- Reduced Environmental Stimulation Therapy (REST) in methamphetamine use disorder: a pilot study.Addictive behaviors reports · 2026Article
- The micro-phenomenology of Floatation-REST.BMC complementary medicine and therapies · 2026Article
- Aquahenosis: a non-pharmacological altered state of consciousness induced by floatation-REST in individuals with anxiety and depression.Neuroscience of consciousness · 2026Article
- Interpreting Anxiety Disorders From the Perspective of Interoceptive Computational Models.Brain and behavior · 2025Review
- Effects of Daytime Floatation-Restricted Environmental Stimulation Therapy on Nocturnal Cardiovascular Physiology, Sleep, and Subjective Recovery in Collegiate Student-Athletes: A Comprehensive Observational Study.Journal of strength and conditioning research · 2025Observational
- Sensing the Self: The Role of the Insula and Interoception in Body Image.Current topics in behavioral neurosciences · 2025Review
- Hypnagogia, psychedelics, and sensory deprivation: the mythic structure of dream-like experiences.Frontiers in psychology · 2025Article
- Short-Term Restriction of Physical and Social Activities Effects on Brain Structure and Connectivity.Brain sciences · 2024Article
- Comparison of 1-hour floatation-REST versus conventional napping on heart rate variability in active individuals.BMJ open sport & exercise medicine · 2024Article
- The impact of floatation therapy on body image and anxiety in anorexia nervosa: a randomised clinical efficacy trial.EClinicalMedicine · 2023Article
- Reduced Environmental Stimulation Therapy (REST) in anxiety and depression: An experience sampling study.Journal of mood and anxiety disorders · 2023Article
- Effect of Psychosocial Interventions for Individuals Who Underwent Arthroscopy in Femoroacetabular Impingement: A Randomized Controlled Trial.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Floatation-REST (Reduced Environmental Stimulation Therapy) reduces sensory input to the nervous system through the act of floating supine in a pool of water saturated with Epsom salt. The float experience is calibrated so that sensory signals from visual, auditory, olfactory, gustatory, thermal, tactile, vestibular, gravitational and proprioceptive channels are minimized, as is most movement and speech. This open-label study aimed to examine whether Floatation-REST would attenuate symptoms of anxiety, stress, and depression in a clinical sample. Fifty participants were recruited across a spectrum of anxiety and stress-related disorders (posttraumatic stress, generalized anxiety, panic, agoraphobia, and social anxiety), most (n = 46) with comorbid unipolar depression. Measures of self-reported affect were collected immediately before and after a 1-hour float session, with the primary outcome measure being the pre- to post-float change score on the Spielberger State Anxiety Inventory. Irrespective of diagnosis, Floatation-REST substantially reduced state anxiety (estimated Cohen's d > 2). Moreover, participants reported significant reductions in stress, muscle tension, pain, depression and negative affect, accompanied by a significant improvement in mood characterized by increases in serenity, relaxation, happiness and overall well-being (p < .0001 for all variables). In reference to a group of 30 non-anxious participants, the effects were found to be more robust in the anxious sample and approaching non-anxious levels during the post-float period. Further analysis revealed that the most severely anxious participants reported the largest effects. Overall, the procedure was well-tolerated, with no major safety concerns stemming from this single session. The findings from this initial study need to be replicated in larger controlled trials, but suggest that Floatation-REST may be a promising technique for transiently reducing the suffering in those with anxiety and depression.
trial registrationClinicalTrials.gov NCT03051074.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.