ArticleAmerican journal of respiratory and critical care medicine2018
A Genome-Wide Association Study in Hispanics/Latinos Identifies Novel Signals for Lung Function. The Hispanic Community Health Study/Study of Latinos.
Open access · greenAbstract readComparative Study
In one paragraph
Article in American journal of respiratory and critical care medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
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30citing papers in PubMed, 2 pooled it
4.9field-weighted citation impact, top 4% of its field
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Who cites it
30 citing papers in PubMed, 2 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- A genome-wide association study of severe asthma exacerbations in Latino children and adolescents.The European respiratory journal · 2021Pooled it
- Multiethnic meta-analysis identifies ancestry-specific and cross-ancestry loci for pulmonary function.Nature communications · 2018Pooled it
- Whole Genome Sequence Analysis of Weight Loss in 16 972 Participants With COPD Reveals Novel Risk Loci in DRAIC and RFX3.Journal of cachexia, sarcopenia and muscle · 2026Article
- Old vs. new local ancestry inference in HCHS/SOL: a comparative study.Human molecular genetics · 2025Article
- Association Between Amerindian Ancestry and Chronic Obstructive Pulmonary Disease in the Chilean Mixed Population.Journal of personalized medicine · 2025Article
- Old vs. New Local Ancestry Inference in HCHS/SOL: A Comparative Study.bioRxiv : the preprint server for biology · 2025Article
- Advancements in genetic research by the Hispanic Community Health Study/Study of Latinos: A 10-year retrospective review.HGG advances · 2025Review
- Monitoring diversity in genome-wide association studies requires measuring and reporting on immigration-related factors.Frontiers in genetics · 2025Article
- Genome-wide analysis in northern Chinese twins identifies twelve new susceptibility loci for pulmonary function.BMC genomics · 2024Article
- Asthma and Chronic Obstructive Pulmonary Disease.Clinics in chest medicine · 2023Review
- Ancestry-driven metabolite variation provides insights into disease states in admixed populations.Genome medicine · 2023Article
- Evolving Science on Cardiovascular Disease Among Hispanic/Latino Adults: JACC International.Journal of the American College of Cardiology · 2023Review
- Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.PLoS genetics · 2023Article
- Genetics of chronic obstructive pulmonary disease: understanding the pathobiology and heterogeneity of a complex disorder.The Lancet. Respiratory medicine · 2022Review
- AFA: Ancestry-specific allele frequency estimation in admixed populations: The Hispanic Community Health Study/Study of Latinos.HGG advances · 2022Article
- A genome-wide association study of quantitative computed tomographic emphysema in Korean populations.Scientific reports · 2021Article
- The AGE-RAGE Axis and RAGE Genetics in Chronic Obstructive Pulmonary Disease.Clinical reviews in allergy & immunology · 2021Review
- An Overview of Strategies for Detecting Genotype-Phenotype Associations Across Ancestrally Diverse Populations.Frontiers in genetics · 2021Review
- Whole genome sequence analysis of pulmonary function and COPD in 19,996 multi-ethnic participants.Nature communications · 2020Article
- Amerindian Ancestry Influences Genetic Susceptibility to Chronic Obstructive Pulmonary Disease.Journal of personalized medicine · 2020Article
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Authors and funding
26 authors at 13 institutions in 4 countries.
Kristin M Burkart1 Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Tamar Sofer2 Division of Sleep and Circadian Disorders, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Stephanie J London4 Epidemiology Branch, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, North Carolina.
Ani Manichaikul5 Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia.
Fernando P Hartwig6 Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Qi Yan7 Division of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
María Soler Artigas8 Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Lydiana Avila9 Division of Pediatric Pulmonology, Hospital Nacional de Niños, San José, Costa Rica.
Wei Chen7 Division of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Sonia Davis Thomas10 Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina.
Alejandro A Diaz11 Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Ian P Hall12 Division of Respiratory Medicine, Queen's Medical Centre, University of Nottingham, Nottingham, United Kingdom.
Bernardo L Horta6 Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Robert C Kaplan13 Department of Epidemiology and Population Health and.
Cathy C Laurie3 Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
Ana M Menezes6 Postgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, Brazil.
Jean V Morrison14 Department of Human Genetics and Statistics, University of Chicago, Chicago, Illinois.
Elizabeth C Oelsner1 Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
Deepa Rastogi15 Department of Pediatrics, Albert Einstein College of Medicine, New York, New York.
Stephen S Rich5 Center for Public Health Genomics, University of Virginia School of Medicine, Charlottesville, Virginia.
Manuel Soto-Quiros7 Division of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
Adrienne M Stilp3 Department of Biostatistics, University of Washington School of Public Health, Seattle, Washington.
Martin D Tobin8 Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Louise V Wain8 Genetic Epidemiology Group, Department of Health Sciences, University of Leicester, Leicester, United Kingdom.
Juan C Celedón7 Division of Pulmonary Medicine, Allergy, and Immunology, Department of Pediatrics, Children's Hospital of Pittsburgh of University of Pittsburgh Medical Center, University of Pittsburgh, Pittsburgh, Pennsylvania.
R Graham Barr1 Department of Medicine, College of Physicians and Surgeons, Columbia University, New York, New York.
University of Pittsburgh · USColumbia University · USUniversidade Federal de Pelotas · BRUniversity of Leicester · GBAlbert Einstein College of Medicine · USBrigham and Women's Hospital · USUniversity of Virginia · USUniversity of Washington · USHospital Nacional de Niños · CRNational Institutes of Health · USUniversity of Chicago · USUniversity of North Carolina at Chapel Hill · USUniversity of Nottingham · GB
Funding
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0MTrue Metal fac coreP30ES009089 · NIEHS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Steven N. Chillrud · 1998 to 2026
$44.7MTransgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MILES Frome WILKINSON · 2003 to 2026
$40.4MPulmonary microvascular perfusion in the Multi-Ethnic Study of AtherosclerosisR01HL077612 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2004 to 2026
$18.8MPulmonary Vascular Changes in Early Chronic Obstructive Pulmonary Disease (COPD)R01HL093081 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI R Graham BARR · 2008 to 2026
$17.2MPhenotypic and Molecular Signatures for Sleep Apnea and Related MorbiditiesR35HL135818 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S. · 2017 to 2023
$7.2MGenetics and Environment in Adult Respiratory, Allergic and Cardiac diseaseZIAES043012 · NIEHS · NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES · PI LONDON, STEPHANIE · 2009 to 2025
$6.4MClinical Implications of Bronchiectasis in SmokersR01HL133137 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2017 to 2021
$2.9MLeveraging ancestral diversity to map adiposity loci in HispanicsR01DK101855 · NIDDK · UNIV OF NORTH CAROLINA CHAPEL HILL · PI HAIMAN, CHRISTOPHER ALAN, LOOS, RUTH JF · 2014 to 2016
$2.1MGenetic and Epigenetic Determinants of Pediatric Obesity-Associated AsthmaK23HL118733 · NHLBI · CHILDREN'S RESEARCH INSTITUTE · PI RASTOGI, DEEPA · 2014 to 2018
$893kComputed Tomographic-Based Assessment of Airway Remodeling in COPDK01HL118714 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI DIAZ, ALEJANDRO · 2013 to 2017
$783kHypercoagulability and Chronic Lung Disease in Older AdultsK23HL130627 · NHLBI · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI OELSNER, ELIZABETH · 2016 to 2019
$686kMedical Research Council G1000861Medical Research Council G1001799Medical Research Council MC_PC_12010Medical Research Council MR/N01104X/1Medical Research Council MR/N01104X/2Medical Research Council MR/N011317/1NCATS NIH HHS UL1 TR000124NHLBI NIH HHS HHSN268201300005CNHLBI NIH HHS K01 HL118714NHLBI NIH HHS K23 HL118733NHLBI NIH HHS K23 HL130627NHLBI NIH HHS N01 HC065233NHLBI NIH HHS N01 HC065234NHLBI NIH HHS N01 HC065235NHLBI NIH HHS N01 HC065236NHLBI NIH HHS N01 HC065237NHLBI NIH HHS R01 HL077612NHLBI NIH HHS R01 HL093081NHLBI NIH HHS R01 HL133137NHLBI NIH HHS R35 HL135818NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R01 DK101855NIEHS NIH HHS P30 ES009089Wellcome Trust 202849/Z/16/Z
Abstract
rationaleLung function and chronic obstructive pulmonary disease (COPD) are heritable traits. Genome-wide association studies (GWAS) have identified numerous pulmonary function and COPD loci, primarily in cohorts of European ancestry.
objectivesPerform a GWAS of COPD phenotypes in Hispanic/Latino populations to identify loci not previously detected in European populations.
methodsGWAS of lung function and COPD in Hispanic/Latino participants from a population-based cohort. We performed replication studies of novel loci in independent studies. MEASUREMENTS AND MAIN
resultsAmong 11,822 Hispanic/Latino participants, we identified eight novel signals; three replicated in independent populations of European Ancestry. A novel locus for FEV
conclusionsWe identified novel signals for lung function and COPD in a Hispanic/Latino cohort. Including admixed populations when performing genetic studies may identify variants contributing to genetic etiologies of COPD.
Indexed as
Genetic Predisposition to DiseaseGenome-Wide Association StudyAdolescentAdultAgedCohort StudiesEuropeFemaleGene FrequencyGenetic LociHispanic or LatinoHumansMaleMiddle AgedPulmonary Disease, Chronic ObstructiveRespiratory Function Testschronic obstructive pulmonary diseasegenome-wide association studyHispanic/Latinolung functionsingle-nucleotide polymorphisms
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