Evidence map›Paper›PMID 29394072›Full record

ArticleJournal of proteome research2018

Molecular Profile of Priapism Associated with Low Nitric Oxide Bioavailability.

Justin D La Favor, Zongming Fu, Vidya Venkatraman, Trinity J Bivalacqua, Jennifer E Van Eyk, Arthur L Burnett

Open access · greenAbstract read
In one paragraph

Article in Journal of proteome research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Justin D La FavorORCID 0000-0002-0845-3421
Zongming Fu
Vidya VenkatramanAdvanced Clinical Biosystems Research Institute, Department of Medicine and The Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California 90048, United States.
Trinity J Bivalacqua
Jennifer E Van EykAdvanced Clinical Biosystems Research Institute, Department of Medicine and The Heart Institute, Cedars-Sinai Medical Center , Los Angeles, California 90048, United States.
Arthur L Burnett
Cedars-Sinai Medical Center · US

Funding

NOS Regulation in the PenisR01DK067223 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BURNETT, ARTHUR LOUIS · 2005 to 2015
$3.5M
Androgen Regulation of Priapism in Sickle Cell DiseaseR01DK093917 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI BURNETT, ARTHUR LOUIS · 2012 to 2015
$1.6M
Regulation of eNOS by S-Nitrosylation in Diet Associated Erectile DysfunctionF32DK100082 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI LAFAVOR, JUSTIN DAVID · 2014 to 2016
$149k
NIDDK NIH HHS F32 DK100082NIDDK NIH HHS R01 DK067223NIDDK NIH HHS R01 DK093917
6 · The paper itself

Abstract

Priapism is a disorder in which prolonged penile erection persists uncontrollably, potentially leading to tissue damage. Priapism commonly afflicts patient populations with severely low nitric oxide (NO) bioavailability. Because NO is a primary mediator of erection, the molecular mechanisms involved in priapism pathophysiology associated with low NO bioavailability are not well-understood. The objective of this study was to identify dysregulated molecular targets and signaling pathways in penile tissue of a mouse model of low NO bioavailability that have potential relevance to priapism. Neuronal plus endothelial NO synthase double knockout mice (NOS1/3

Indexed as

AnimalsChromatography, Reverse-PhaseCyclic AMP-Dependent Protein KinasesDisease Models, AnimalElectric StimulationEndothelial CellsGene Expression RegulationGene OntologyHumansMaleMiceMice, KnockoutMolecular Sequence AnnotationNeuronsNitric OxideNitric Oxide Synthase Type ICyclic AMP-Dependent Protein KinasesNitric OxideNitric Oxide Synthase Type INitric Oxide Synthase Type IIINos1 protein, mouseNos3 protein, mouseProteomeReceptors, G-Protein-CouplederectileGPCRmass spectrometrynitric oxidepenisPKApriapismproteomics

Identifiers

PMID29394072
PMCPMC6419954
OpenAlexW2786856398

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.