Evidence map›Paper›PMID 29394063›Full record

ArticleJournal of natural products2018

Anti-Influenza Triterpene Saponins from the Bark of Burkea africana.

Christina E Mair, Ulrike Grienke, Anke Wilhelm, Ernst Urban, Martin Zehl, Michaela Schmidtke, Judith M Rollinger

Open access · hybridAbstract read
In one paragraph

Article in Journal of natural products, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Deoxyshikonin Inhibits Influenza A Virus Infection at an Early Stage.International journal of molecular sciences · 2025
    Article
  5. Anti-Viral Activity of Conessine Against Influenza A Virus.International journal of molecular sciences · 2025
    Article
  6. Antiviral Activity of Berbamine Against Influenza A Virus Infection.International journal of molecular sciences · 2025
    Article
  7. Oleraceins fromCurrent research in food science · 2025
    Article
  8. Review
  9. Review
  10. Review
  11. PhytoestrogenVaccines · 2023
    Article
  12. Article
  13. Review
  14. Anti-viral triterpenes: a review.Phytochemistry reviews : proceedings of the Phytochemical Society of Europe · 2022
    Review
  15. Article
  16. Article
  17. Review
  18. Steroidal saponins from the roots of Solanum sisymbriifolium Lam. (Solanaceae) have inhibitory activity against dengue virus and yellow fever virus.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2021
    Article
  19. Review
  20. Biomolecules · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 3 countries.

Christina E MairDepartment of Pharmacognosy, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , 1090 Vienna , Austria.
Ulrike GrienkeDepartment of Pharmacognosy, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , 1090 Vienna , Austria.ORCID 0000-0003-0305-9270
Anke WilhelmDepartment of Chemistry , University of the Free State , PO Box 339, 9300 Bloemfontein , South Africa.ORCID 0000-0003-4561-5589
Ernst UrbanDepartment of Pharmaceutical Chemistry, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , 1090 Vienna , Austria.
Martin ZehlDepartment of Pharmacognosy, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , 1090 Vienna , Austria.ORCID 0000-0001-9685-0373
Michaela SchmidtkeInstitute of Medical Microbiology, Section Experimental Virology, Jena University Hospital , Hans-Knöll-Straße 2 , 07745 Jena , Germany.
Judith M RollingerDepartment of Pharmacognosy, Faculty of Life Sciences , University of Vienna , Althanstraße 14 , 1090 Vienna , Austria.ORCID 0000-0001-6581-0774
University of Vienna · ATJena University Hospital · DEUniversity of the Free State · ZA

Funding

Austrian Science Fund FWF P 24587
6 · The paper itself

Abstract

In an in vitro cytopathic effect inhibition assay with the H3N2 influenza virus A/Hong Kong/68 (HK/68), the bark extract of Burkea africana was found to be a promising antiviral lead with an IC

Indexed as

AnimalsAntiviral AgentsCytotoxinsDogsFabaceaeHumansInfluenza A Virus, H1N1 SubtypeInfluenza A Virus, H3N2 SubtypeInhibitory Concentration 50Madin Darby Canine Kidney CellsOleanolic AcidOrthomyxoviridae InfectionsPentacyclic TriterpenesSaponinsTriterpenesAntiviral AgentsCytotoxinslupaneoleananeOleanolic AcidPentacyclic TriterpenesSaponinsTriterpenes

Identifiers

PMID29394063
PMCPMC5869419
OpenAlexW2789241914

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.