Evidence map›Paper›PMID 29393894›Full record

ArticleDiagnostics (Basel, Switzerland)2018

Comparison of a New Multiplex Immunoassay for Measurement of Ferritin, Soluble Transferrin Receptor, Retinol-Binding Protein, C-Reactive Protein and α¹-Acid-glycoprotein Concentrations against a Widely-Used s-ELISA Method.

Crystal D Karakochuk, Amanda M Henderson, Kaitlyn L I Samson, Abeer M Aljaadi, Angela M Devlin, Elodie Becquey, James P Wirth, Fabian Rohner

Open access · goldAbstract read
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Crystal D KarakochukFood, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. crystal.karakochuk@ubc.ca.ORCID 0000-0002-1025-2194
Amanda M HendersonBC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada. ahenderson@bcchr.ca.
Kaitlyn L I SamsonFood, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. kaitlyn.samson@ubc.ca.
Abeer M AljaadiFood, Nutrition, and Health, University of British Columbia, Vancouver, BC V6T 1Z4, Canada. aaljaadi@bcchr.ca.
Angela M DevlinBC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada. adevlin@bcchr.ca.
Elodie BecqueyInternational Food Policy Research Institute, Washington, DC 20005, USA. e.becquey@cgiar.org.
James P WirthGroundWork, Fläsch 7306, Switzerland. james@groundworkhealth.org.
Fabian RohnerGroundWork, Fläsch 7306, Switzerland. fabian@groundworkhealth.org.ORCID 0000-0003-0579-6952
University of British Columbia · CAInternational Food Policy Research Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recently, a multiplex ELISA (Quansys Biosciences) was developed that measures ferritin, soluble transferrin receptor (sTfR), retinol-binding protein (RBP), C-reactive protein (CRP), α¹-acid glycoprotein (AGP), thyroglobulin, and histidine-rich protein 2. Our primary aim was to conduct a method-comparison study to compare five biomarkers (ferritin, sTfR, RBP, CRP, and AGP) measured with the Quansys assay and a widely-used s-ELISA (VitMin Lab, Willstaett, Germany) with use of serum samples from 180 women and children from Burkina Faso, Cambodia, and Malaysia. Bias and concordance were used to describe the agreement in values measured by the two methods. We observed poor overall agreement between the methods, both with regard to biomarker concentrations and deficiency prevalence estimates. Several measurements were outside of the limit of detection with use of the Quansys ELISA (total

Indexed as

C-reactive proteinELISAferritinimmunoassayinflammationmicronutrientretinol-binding proteinsoluble transferrin receptorα1-acid glycoprotein

Identifiers

PMID29393894
PMCPMC5871996
OpenAlexW2791455933

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.