ReviewAmerican journal of physiology. Heart and circulatory physiology2018
A population neuroscience approach to the study of cerebral small vessel disease in midlife and late life: an invited review.
Review in American journal of physiology. Heart and circulatory physiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
46 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Global ethnic disparities in cerebral small vessel disease imaging markers and vascular risk factors: a systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Pooled it
- Remote ischemic conditioning after stroke: Research progress in clinical study.CNS neuroscience & therapeutics · 2024Pooled it
- Genetically predicted white matter microstructure mediates the relationship between risk factors and lacunar stroke.Stroke and vascular neurology · 2026Article
- Modulatory Effects of Hypertension on Aging-Related White Matter Hyperintensities: A Comparative Study Among Stroke Patients and Stroke-Free Community-Based Cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Racial Differences in Small Vessel Disease Measured in MRI of Ischemic Stroke/TIA Patients.Journal of neurological disorders & stroke · 2025Article
- The expression and association of MATK in chronic hypoperfusion patients with white matter hyperintensity.Frontiers in aging neuroscience · 2025Article
- Common protein-altering variant in GFAP is associated with white matter lesions in the older Japanese population.NPJ genomic medicine · 2024Article
- Can white matter hyperintensities based Fazekas visual assessment scales inform about Alzheimer's disease pathology in the population?Alzheimer's research & therapy · 2024Article
- The Role of Aging in Intracerebral Hemorrhage.Brain sciences · 2024Review
- Clinical Predictors of Postmortem Amyloid and Nonamyloid Cerebral Small Vessel Disease in Middle-Aged to Older Adults.Neurology. Clinical practice · 2024Article
- Advancements in investigating the role of cerebral small vein loss in Alzheimer's disease-related pathological changes.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- White matter hyperintensity patterns: associations with comorbidities, amyloid, and cognition.Alzheimer's research & therapy · 2024Article
- The PREVENT dementia programme: baseline demographic, lifestyle, imaging and cognitive data from a midlife cohort study investigating risk factors for dementia.Brain communications · 2024Article
- Progression of white matter hyperintensities is related to blood pressure increases and global cognitive decline - A registered report.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Racial, Ethnic, and Geographic Diversity in Population Neuroscience.Current topics in behavioral neurosciences · 2024Review
- Distinct cerebral small vessel disease impairment in early- and late-onset Alzheimer's disease.Annals of clinical and translational neurology · 2023Article
- Article
- Topography of associations between cardiovascular risk factors and myelin loss in the ageing human brain.Communications biology · 2023Article
- Investigating the factors that explain white matter hyperintensity load in older Indians.Brain communications · 2023Article
- Cardiometabolic health across menopausal years is linked to white matter hyperintensities up to a decade later.Frontiers in global women's health · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Aging in later life engenders numerous changes to the cerebral microvasculature. Such changes can remain clinically silent but are associated with greater risk for negative health outcomes over time. Knowledge is limited about the pathogenesis, prevention, and treatment of potentially detrimental changes in the cerebral microvasculature that occur with advancing age. In this review, we summarize literature on aging of the cerebral microvasculature, and we propose a conceptual framework to fill existing research gaps and advance future work on this heterogeneous phenomenon. We propose that the major gaps in this area are attributable to an incomplete characterization of cerebrovascular pathology, the populations being studied, and the temporality of exposure to risk factors. Specifically, currently available measures of age-related cerebral microvasculature changes are indirect, primarily related to parenchymal damage rather than direct quantification of small vessel damage, limiting the understanding of cerebral small vessel disease (cSVD) itself. Moreover, studies seldom account for variability in the health-related conditions or interactions with risk factors, which are likely determinants of cSVD pathogenesis. Finally, study designs are predominantly cross-sectional and/or have relied on single time point measures, leaving no clear evidence of time trajectories of risk factors or of change in cerebral microvasculature. We argue that more resources should be invested in 1) developing methodological approaches and basic science models to better understand the pathogenic and etiological nature of age-related brain microvascular diseases and 2) implementing state-of-the-science population study designs that account for the temporal evolution of cerebral microvascular changes in diverse populations across the lifespan.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.