ArticleCaries research2018
Redefining the Phenotype of Dental Caries.
Article in Caries research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Genes in the pathway of tooth mineral tissues and dental caries risk: a systematic review and meta-analysis.Clinical oral investigations · 2020Pooled it
- Effect of immediate and delayed composite restoration on shear bond strength to remineralized initial enamel lesions: an in vitro study.The Saudi dental journal · 2026Article
- Allelic and Genotypic Distribution ofClinics and practice · 2025Article
- Knowledge, attitude and practice towards oral health in parents and teachers of kindergarten students: a cross-sectional survey.BMJ open · 2025Article
- Caries Risk Assessment by Dental Students and Dentists in the Netherlands: A Survey Study to Assess Knowledge and Implementation.Caries research · 2025Article
- Polymorphisms inThe Saudi dental journal · 2024Article
- Association of Dental Caries in Primary Teeth With HLA Class II Gene Among Syrian Children.Cureus · 2024Article
- Association between polymorphisms of immune response genes and early childhood caries - systematic review, gene-based, gene cluster, and meta-analysis.Journal, genetic engineering & biotechnology · 2023Review
- Dental Caries Risk Assessment in Children 5 Years Old and under via Machine Learning.Dentistry journal · 2022Article
- Current State and Challenges of the Global Outcomes of Dental Caries Research in the Meta-Omics Era.Frontiers in cellular and infection microbiology · 2022Review
- Genetic Aspects of Dental Erosive Wear and Dental Caries.International journal of dentistry · 2021Review
- Biomarkers for Lifetime Caries-Free Status.Journal of personalized medicine · 2020Article
- When to intervene in the caries process? A Delphi consensus statement.British dental journal · 2020Article
- Enamel and Dentin Caries Risk Factors of Adolescents in the Context of the International Caries Detection and Assessment System (ICDAS): A Longitudinal Study.Frontiers in pediatrics · 2020Article
- When to intervene in the caries process? An expert Delphi consensus statement.Clinical oral investigations · 2019Article
- Are mTOR and Endoplasmic Reticulum Stress Pathway Genes Associated with Oral and Bone Diseases?Caries research · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Dental caries is a multifactorial infectious disease and a major public health problem estimated to affect 60-90% of school children as well as a vast number of adults. The aim of this work was to define patterns of progression of the disease based on longitudinal data in contrast to using a cross-sectional assessment. dmft/DMFT scores were collected at ages 5, 12, 14, 16, 17, and 18 from 876 individuals. We tested our newly defined phenotypes for association with genetic variants in genes shown to be associated with caries. We generated genotyping data using Taqman chemistry in markers of genes involved in processes such as enamel formation and salivary contributions. Kallikrein 4 (KLK4) was found to show a significant association with the created phenotypes (p = 0.0008 in a recessive model for low caries experience in the primary dentition vs. high caries experience in the primary dentition, and p = 0.0004 in a recessive model for caries free primary dentition vs. high caries experience in the primary dentition).
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.