Evidence map›Paper›PMID 29392651›Full record

SynthesisIrish journal of medical science2018

The role of liver resection in patients with metastatic breast cancer: a systematic review examining the survival impact.

Sadia Tasleem, Jarlath C Bolger, Michael E Kelly, Michael R Boland, Dermot Bowden, Karl J Sweeney, Carmel Malone

Abstract readMeta-AnalysisSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Review
  10. Surgical therapy for breast cancer liver metastases.Translational cancer research · 2020
    Review
  11. Article
  12. [Role of visceral surgery in oligometastases of non-gastrointestinal tumors].Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Sadia TasleemDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.
Jarlath C BolgerDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland. jarbolger@rcsi.ie.ORCID http://orcid.org/0000-0002-0796-633X
Michael E KellyDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.
Michael R BolandDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.
Dermot BowdenDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.
Karl J SweeneyDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.
Carmel MaloneDepartment of Breast Surgery, University Hospital Galway, Saolta University Hospital Group, Galway, Ireland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionApproximately 10% of breast cancer patients will present with solid organ metastases, while up to 30% will develop metastatic disease during their treatment course. Liver metastases are usually treated with systemic chemotherapy. Although colorectal liver metastases are routinely resected, this is not yet the standard of care for breast cancer-related liver metastases. This review examines the evidence for resection of breast cancer-related liver metastases.

methodsA systematic review identified 25 articles for inclusion, 12 papers concerning patients with isolated liver metastases, and 13 papers concerning patients with extrahepatic metastases. Data from 1080 patients were included.

resultsTwo hundred eighty patients underwent hepatic resections for breast cancer-associated metastases with no extrahepatic metastases. Reported 5-year survival ranged from 24.6 to 78%. Median overall survival ranged from 29.5 to 116 months. For patients with oligometastatic disease undergoing resection, 5-year survival ranged from 21 to 57%, with median overall survival ranging from 32 to 58 months. Reported 30-day morbidity ranged from 14 to 42% for isolated and multiple metastases.

conclusionHepatic resection can be considered in the management of breast cancer patients with isolated liver metastases as well as those with oligometastatic disease.

Indexed as

Breast NeoplasmsFemaleHepatectomyHumansLiver NeoplasmsMiddle AgedSurvival RateTreatment OutcomeBreast cancerMetastatic breast cancerSurgical outcomesSurvival

Identifiers

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.