SynthesisIrish journal of medical science2018
Cytomegalovirus infection and steroid-refractory inflammatory bowel disease: possible relationship from an updated meta-analysis.
Synthesis in Irish journal of medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Tissue Cytomegalovirus DNA Detection by PCR Is Associated with Increased Endoscopic Activity in Ulcerative Colitis: A Retrospective Cohort Study.Biomedicines · 2026Article
- Cytomegalovirus Infection: An Underrated Target in Inflammatory Bowel Disease Treatment.Journal of clinical medicine · 2023Review
- Cytomegalovirus Pneumonia in Inflammatory Bowel Disease: Literature Review and Clinical Recommendations.Infection and drug resistance · 2023Review
- [Cytomegalovirus Infection in Patients with Inflammatory Bowel Disease].The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2022Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsMany studies have suggested Cytomegalovirus infection might be implicated in steroid-refractory inflammatory bowel disease (IBD), in which situation management is extremely difficult. CMV infection being a potential cause of IBD have drawn great attention of clinicians, with insufficient evidence to reach conclusions.
methodsWe conduct this meta-analysis to explore the association of CMV infection and steroid-refractory IBD by collecting relevant articles. Literature collections were conducted by searching PubMed, EMBASE, and the cochrane library databases. Pooled risk ratios (RR) with corresponding 95% confidence intervals (CIs) were calculated to estimate the strength of the link between CMV infection and steroid resistance in IBD using Stata 12.0.
resultsThirteen eligible studies with a total of 1119 patients conducted in eight countries were included. The steroid resistance rate in the CMV (+) groups was 62.8%, while that in the CMV (-) groups was 29.2%. The pooled RR of steroid resistance rate in CMV (+) groups compared to CMV (-) groups was 2.343 (95% CI 1.715-3.202, P = 0.0000). Due to marginal heterogeneity across studies (I
conclusionsThis meta-analysis disclosed 2.34 fold increased risk of progressing into steroid-refractory IBD in CMV (+) group compared with the CMV (-) group, indicating that CMV infection might be a plausible cause of steroid-refractory IBD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.