ArticleJournal of microbiology (Seoul, Korea)2018
A common evolutionary pathway for maintaining quorum sensing in Pseudomonas aeruginosa.
Article in Journal of microbiology (Seoul, Korea), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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8 citing papers in PubMed, 14 citations in OpenAlex.
- Challenging the paradigm: non-canonical exoprotease cheating in clinical Pseudomonas aeruginosa isolates.FEMS microbiology ecology · 2025Article
- Role of horizontal gene transfer and cooperation in rhizosphere microbiome assembly.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2025Review
- Article
- 3-Phenylpropan-1-Amine Enhanced Susceptibility of Serratia marcescens to Ofloxacin by Occluding Quorum Sensing.Microbiology spectrum · 2022Article
- Tobramycin Adaptation Enhances Policing of Social Cheaters in Pseudomonas aeruginosa.Applied and environmental microbiology · 2021Article
- Quercus infectoria gall extracts reduce quorum sensing-controlled virulence factors production and biofilm formation in Pseudomonas aeruginosa recovered from burn wounds.BMC complementary and alternative medicine · 2019Article
- Seeding Public Goods Is Essential for Maintaining Cooperation inFrontiers in microbiology · 2019Article
- Pyocyanin Restricts Social Cheating inFrontiers in microbiology · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the bacterium Pseudomonas aeruginosa, the synthesis and secretion of extracellular protease is a typical cooperative behavior regulated by quorum sensing. However, this type of cooperative behavior is easily exploited by other individuals who do not synthesize public goods, which is known as the "tragedy of the commons". Here P. aeruginosa was inoculated into casein media with different nitrogen salts added. In casein broth, protease (a type of public good) is necessary for bacterial growth. After 30 days of sequential transfer, some groups propagated stably and avoided "tragedy of the commons". The evolved cooperators who continued to synthesize protease were isolated from these stable groups. By comparing the characteristics of quorum sensing in these cooperators, an identical evolutionary pattern was found. A variety of cooperative behaviors regulated by quorum sensing, such as the synthesis and secretion of protease and signals, were significantly reduced during the process of evolution. Such reductions improved the efficiency of cooperation, helping to prevent cheating. In addition, the production of pyocyanin, which is regulated by the RhlIR system, increased during the process of evolution, possibly due to its role in stabilizing the cooperation. This study contributes towards our understanding of the evolution of quorum sensing of P. aeruginosa.
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