Evidence map›Paper›PMID 29392459›Full record

Trial reportJournal of neurology2018

Patient-centered integrated healthcare improves quality of life in Parkinson's disease patients: a randomized controlled trial.

Carsten Eggers, R Dano, J Schill, G R Fink, M Hellmich, L Timmermann, CPN study group

Abstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of neurology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 6 pooled it
5.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 6 syntheses or guidelines pooled it, 77 citations in OpenAlex.

  1. Pooled it
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  5. Guideline
  6. Pooled it
  7. Article
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  11. Observational
  12. Review
  13. Article
  14. Breaking barriers in Parkinson's care: the multidisciplinary team approach.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  15. Article
  16. Multidisciplinary care in Parkinson's disease.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Article
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Carsten EggersDepartment of Neurology, University of Cologne, Cologne, Germany. carsten.eggers@uk-gm.de.
R DanoDepartment of Neurology, University of Cologne, Cologne, Germany.
J SchillDepartment of Neurology, University of Cologne, Cologne, Germany.
G R FinkDepartment of Neurology, University of Cologne, Cologne, Germany.
M HellmichInstitute of Medical Statistics and Computational Biology, University of Cologne, Cologne, Germany.
L TimmermannDepartment of Neurology, University of Cologne, Cologne, Germany.
CPN study group
Philipps University of Marburg · DEForschungszentrum Jülich · DEUniversity of Cologne · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionImproving quality of life (QoL) is a key issue when dealing with Parkinson's disease (PD). Integrative care shows potential to achieve improvements in QoL. Here, we analyzed whether a community-based, open-label, integrated approach improves QoL in PD patients.

methodsPD patients were screened for eligibility and evaluated by a university-based PD specialist, a PD nurse, and a general neurologist at a local practice. Patients were randomly assigned to a control group (CG), receiving standard German neurological treatment including a baseline assessment and follow-up visit at 6 months, or an interventional group (IG) who received an individually tailored therapy plan and additional home visits. Patients and investigators were not blinded for either intervention. Primary outcome analysis compared the differential change of PDQ-39 from baseline to 6-month follow-up between CG and IG. Between-group changes in mood, motor/non-motor functioning, and cognition were secondary outcomes.

results300 patients were included and randomized equally to IG and CG. 132 IG and 125 CG patients had a valid PDQ-39 at follow-up and qualified for the modified ITT analysis. PDQ-39 improved more in IG compared to CG [2.2 points (95% CI - 4.4 to 0.1); p = 0.044]. Likewise, change scores between IG and CG favored IG for UPDRS III (p < 0.001, mean change 3.3, 95% CI - 4.9 to - 1.7) and PD-NMS (p < 0.001, mean change 11.3, 95% CI - 17.1 to - 5.5).

conclusionsData show that an integrated approach, compared to regular PD care, improves QoL as well as motor and nonmotor PD symptoms over 6 months. Future studies need to address the cost-benefit ratio and whether positive effects can be maintained beyond intervention.

Indexed as

Disease ManagementAgedAged, 80 and overFemaleFollow-Up StudiesHumansMaleMiddle AgedParkinson DiseasePrimary Health CareQuality of LifeRetrospective StudiesSeverity of Illness IndexTreatment OutcomeAllied healthIntegrated careMultidisciplinaryParkinsonQuality of life

Identifiers

PMID29392459
OpenAlexW2785869702

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.