ArticlePain reports2017
Mice with cancer-induced bone pain show a marked decline in day/night activity.
Article in Pain reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 14 citations in OpenAlex.
- The contribution of stem cell factor and its receptor c-Kit to cancer-induced bone pain.JCI insight · 2026Article
- Crosstalk between bone metastatic cancer cells and sensory nerves in bone metastatic progression.Life science alliance · 2024Article
- Mechanisms of bone pain: Progress in research from bench to bedside.Bone research · 2022Review
- A Mouse Model of Cancer Induced Bone Pain: From Pain to Movement.Frontiers in behavioral neuroscience · 2022Article
- Intrathecal Oxytocin Improves Spontaneous Behavior and Reduces Mechanical Hypersensitivity in a Rat Model of Postoperative Pain.Frontiers in pharmacology · 2020Article
- Multiple myeloma increases nerve growth factor and other pain-related markers through interactions with the bone microenvironment.Scientific reports · 2019Article
- Nerves in Bone: Evolving Concepts in Pain and Anabolism.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Review
- Bone Metastasis Pain, from the Bench to the Bedside.International journal of molecular sciences · 2019Review
- The Changing Sensory and Sympathetic Innervation of the Young, Adult and Aging Mouse Femur.Neuroscience · 2018Article
- Article
- Wheel Running in Digital Ventilated CagesIn vivo (Athens, Greece)Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
introductionCancer-induced bone pain (CIBP) is the most common type of pain with cancer. In humans, this pain can be difficult to control and highly disabling. A major problem with CIBP in humans is that it increases on weight-bearing and/or movement of a tumor-bearing bone limiting the activity and functional status of the patient. Currently, there is less data concerning whether similar negative changes in activity occur in rodent models of CIBP.
objectivesTo determine whether there are marked changes in activity in a rodent model of CIBP and compare this to changes in skin hypersensitivity.
methodsOsteosarcoma cells were injected and confined to 1 femur of the adult male mouse. Every 7 days, spontaneous horizontal and vertical activities were assessed over a 20-hour day and night period using automated activity boxes. Mechanical hypersensitivity of the hind paw skin was assessed using von Frey testing.
resultsAs the tumor cells grew within the femur, there was a significant decline in horizontal and vertical activity during the times of the day/night when the mice are normally most active. Mice also developed significant hypersensitivity in the skin of the hind paw in the tumor-bearing limb.
conclusionEven when the tumor is confined to a single load-bearing bone, CIBP drives a significant loss of activity, which increases with disease progression. Understanding the mechanisms that drive this reduction in activity may allow the development of therapies that allow CIBP patients to better maintain their activity and functional status.
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