Evidence map›Paper›PMID 29392225›Full record

ArticlePain reports2017

Effect of the spider toxin Tx3-3 on spinal processing of sensory information in naive and neuropathic rats: an in vivo electrophysiological study.

Gerusa D Dalmolin, Kirsty Bannister, Leonor Gonçalves, Shafaq Sikandar, Ryan Patel, Marta do Nascimento Cordeiro, Marcus Vinícius Gomez, Juliano Ferreira, Anthony H Dickenson

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pain reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Pain-related toxins in scorpion and spider venoms: a face to face with ion channels.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  5. Anti-inflammatory activities of arthropod peptides: a systematic review.The journal of venomous animals and toxins including tropical diseases · 2021
    Review
  6. Translational issues in precision medicine in neuropathic pain.Canadian journal of pain = Revue canadienne de la douleur · 2020
    Review
  7. Article
  8. Spider venom peptides as potential drug candidates due to their anticancer and antinociceptive activities.The journal of venomous animals and toxins including tropical diseases · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Gerusa D DalmolinDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
Kirsty BannisterDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
Leonor GonçalvesDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
Shafaq SikandarDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
Ryan PatelDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
Marta do Nascimento CordeiroEzequiel Dias Foundation, Belo Horizonte, MG, Brazil.
Marcus Vinícius GomezResearch Institute of Santa Casa de Belo Horizonte, Belo Horizonte, MG, Brazil.
Juliano FerreiraDepartment of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil.
Anthony H DickensonDepartment of Neuroscience, Physiology and Pharmacology, University College London, London, United Kingdom. Dalmolin is now with Department of Pharmacology, Federal University of Santa Catarina, Florianópolis, SC, Brazil. Sikandar is now with Wolfson Institute of Biomedical Research, University College London, London, United Kingdom.
University College London · GBUniversidade Federal de Santa Catarina · BREzequiel Dias Foundation · BRInstituto de Ensino e Pesquisa Santa Casa · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionDrugs that counteract nociceptive transmission in the spinal dorsal horn preferentially after nerve injury are being pursued as possible neuropathic pain treatments. In a previous behavioural study, the peptide toxin Tx3-3, which blocks P/Q- and R-type voltage-gated calcium channels, was effective in neuropathic pain models.

objectivesIn the present study, we aimed to investigate the effect of Tx3-3 on dorsal horn neuronal responses in rats under physiological conditions and neuropathic pain condition induced by spinal nerve ligation (SNL).

methodsIn vivo electrophysiological recordings of dorsal horn neuronal response to electrical and natural (mechanical and thermal) stimuli were made in rats under normal physiological state (naive rats) or after the SNL model of neuropathic pain.

resultsTx3-3 (0.3-100 pmol/site) exhibited greater inhibitory effect on electrical-evoked neuronal response of SNL rats than naive rats, inhibiting nociceptive C-fibre and Aδ-fibre responses only in SNL rats. The wind-up of neurones, a measurement of spinal cord hyperexcitability, was also more susceptible to a dose-related inhibition by Tx3-3 after nerve injury. Moreover, Tx3-3 exhibited higher potency to inhibit mechanical- and thermal-evoked neuronal response in conditions of neuropathy.

conclusionTx3-3 mediated differential inhibitory effect under physiological and neuropathic conditions, exhibiting greater potency in conditions of neuropathic pain.

Indexed as

In vivo electrophysiologyNeuropathic painPeptide toxinSpinal cordVoltage-gated calcium channel

Identifiers

PMID29392225
PMCPMC5741365
OpenAlexW2730311787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.