ArticlePain reports2017
Women report higher pain intensity at a lower level of inflammation after knee surgery compared with men.
Article in Pain reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Interleukin-6 and Interleukin-8 Gene Expressions Differ Between Male and Female Patients at Time of Hip Arthroscopy for Femoroacetabular Impingement Syndrome.Arthroscopy, sports medicine, and rehabilitation · 2024Article
- The influence of sex on neuroimmune communication, pain, and physiology.Biology of sex differences · 2024Review
- Sexual dimorphism in peri-articular tissue anatomy - More keys to understanding sex-differences in osteoarthritis?Osteoarthritis and cartilage open · 2024Review
- Osteocytes contribute to sex-specific differences in osteoarthritic pain.Frontiers in endocrinology · 2024Article
- A Brief Overview: Sex Differences in Prevalent Chronic Musculoskeletal Conditions.International journal of environmental research and public health · 2023Article
- Factors associated with persistent postsurgical pain after total knee or hip joint replacement: a systematic review and meta-analysis.Pain reports · 2023Review
- Sociodemographic and Clinical Characteristics Associated With Worst Pain Intensity Among Cancer Patients.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022Article
- Patient Race, Ethnicity, Language, and Pain Severity in Primary Care: A Retrospective Electronic Health Record Study.Pain management nursing : official journal of the American Society of Pain Management Nurses · 2022Article
- Machine-Learning Analysis of Serum Proteomics in Neuropathic Pain after Nerve Injury in Breast Cancer Surgery Points at Chemokine Signaling via SIRT2 Regulation.International journal of molecular sciences · 2022Article
- Innate Immunity at the Core of Sex Differences in Osteoarthritic Pain?Frontiers in pharmacology · 2022Review
- Sensory Neurons, Neuroimmunity, and Pain Modulation by Sex Hormones.Endocrinology · 2021Review
- Gender and Sex Are Key Determinants in Osteoarthritis Not Only Confounding Variables. A Systematic Review of Clinical Data.Journal of clinical medicine · 2021Review
- Article
- Proximity Extension Assay in Combination with Next-Generation Sequencing for High-throughput Proteome-wide Analysis.Molecular & cellular proteomics : MCP · 2021Article
- Effects of menstrual cycle on nausea and vomiting after general anesthesia.Journal of anesthesia · 2020Article
- Compression Stocking Length Effects on Oedema, Pain, and Satisfaction in Nursing Students: A Pilot Randomized Trial.Healthcare (Basel, Switzerland) · 2020Article
- Association Between HIV Symptom Burden and Inflammatory Cytokines: An Analysis by Sex and Menopause Stage.Journal of women's health (2002) · 2020Article
- Impact of Patient Demographic Factors on Preoperative Patient-Reported Outcomes Measurement Information System (PROMIS) Physical Function, Pain Interference, and Depression Computer Adaptive Testing Scores in Patients Undergoing Shoulder and Elbow Surgery.Orthopaedic journal of sports medicine · 2019Article
- Sex differences in the relationship between individual systemic markers of inflammation and pain in knee osteoarthritis.Osteoarthritis and cartilage openArticle
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
INTRODUCTION AND
objectivesWe previously found that women report more pain after knee arthroscopic procedures than men. It remains unclear whether this is due to different biochemical responses or nociceptive mechanisms.
methodsWe analyzed acute pain-related inflammatory markers in a clinical model of patient self-reported pain immediately after knee surgery. To simultaneously measure 92 inflammatory biomarkers, we used the proximity extension assay with the Proseek Multiplex Inflammation I panel (Olink Bioscience, Uppsala, Sweden). Knee surgery was performed under general anesthesia with propofol and remifentanil. Analgesic drugs were only administered on patient request.
resultsWomen were 4.9 times more likely to report moderate or severe pain than men (95% confidence interval, 1.2-19.6,
conclusionAcute pain after knee arthroscopy was more intense in women, but pro-inflammatory biomarkers and MMP-10 were higher in men. Further knowledge of cytokine function is required before concluding that the disparities in biomarker expression are clinically unimportant. The similar biochemical signaling between sexes suggests that central mechanisms are of greater importance in sex-specific joint pain perception.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.