ArticlePain reports2017
Postoperative pain-from mechanisms to treatment.
Article in Pain reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 178 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Efficacy of Pre-emptive Tapentadol vs Pregabalin in Post Operative Pain Following Unilateral Total Knee Arthroplasty- A Randomised, Double Blind, Active Control, Clinical Trial
Pain Trajectories in Severe Persistent Inguinal Post-herniorrhaphy Pain
Photobiomodulation on Postoperative Pain
Preoperative Moderate-to-vigorous Intensity Physical Activities Reduce Postoperative Pain in Adults
Professor, School of Nursing, China Medical University Hospital, Principal Investigator
Who cites it
178 citing papers in PubMed, 5 syntheses or guidelines pooled it, 387 citations in OpenAlex.
- Effects of acupoint stimulation for postoperative analgesia after Cesarean delivery: a systematic review and meta-analysis of randomized controlled trials.Canadian journal of anaesthesia = Journal canadien d'anesthesie · 2026Pooled it
- Hotspots and frontiers in chronic postoperative pain: a bibliometric analysis and review (2004-2025).Frontiers in medicine · 2026Pooled it
- Strategy for effective analgesia with intravenous buprenorphine in patients with acute postoperative pain.BMC anesthesiology · 2025Pooled it
- Pooled it
- Dexmedetomidine and sufentanil combination versus sufentanil alone for postoperative intravenous patient-controlled analgesia: a systematic review and meta-analysis of randomized controlled trials.BMC anesthesiology · 2019Pooled it
- Effectiveness of elastic therapeutic taping in pain management after median sternotomy: A randomized controlled trial.PloS one · 2026Trial
- Hydromorphone is Noninferior to Dexamethasone as an Adjuvant to Ropivacaine for Transversus Abdominis Plane Block After Laparoscopic Colorectal Cancer Surgery: A Randomized, Double-Blind Trial.Journal of pain research · 2026Trial
- Effects of Positive Psychotherapy-Based Education on Pain, Psychological Resilience, and Mental Well-Being After Lumbar Canal Stenosis Surgery: A Randomized Controlled Trial.Brain and behavior · 2025Trial
- Comparative efficacy of memantine and vitamin C in postoperative pain management: a randomized clinical trial.Pain management · 2025Trial
- Effect of electroacupuncture on pain after periodontal flap surgery: a randomized controlled trial.Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan · 2025Trial
- Co-crystal of Tramadol-Celecoxib Versus Tramadol or Placebo for Acute Moderate-to-Severe Pain After Oral Surgery: Randomized, Double-Blind, Phase 3 Trial (STARDOM1).Advances in therapy · 2024Trial
- Comparison of the analgesic efficacy of spray and tablet flurbiprofen for pain after soft tissue surgery.Brazilian oral research · 2024Trial
- Effects of ultrasound-guided erector spinae plane block on postoperative acute pain and chronic post-surgical pain in patients underwent video-assisted thoracoscopic lobectomy: a prospective randomized, controlled trial.BMC anesthesiology · 2023Trial
- The analgesic effect of total intravenous anaesthesia with propofol versus inhalational anaesthesia for acute postoperative pain after hepatectomy: a randomized controlled trial.BMC anesthesiology · 2023Trial
- EEG-derived pain threshold index for prediction of postoperative pain in patients undergoing laparoscopic urological surgery: a comparison with surgical pleth index.Journal of clinical monitoring and computing · 2021Trial
- Efficacy of celecoxib as preemptive analgesia for patients undergoing laparoscopic inguinal hernia repair: a randomized trial.Surgery today · 2021Trial
- Trial
- Individualizing Perioperative Analgesia: Patient-Specific Determinants of Postoperative Pain and Opioid-Related Outcomes.Medicina (Kaunas, Lithuania) · 2026Review
- Triple-layered core-shell microneedle patch for sustained analgesic delivery and chondroprotection in osteoarthritis.Journal of controlled release : official journal of the Controlled Release Society · 2026Article
- Differentiating Normal Healing From Infection in Total Joint Arthroplasty: An Educational and Diagnostic Tool for Emergency Providers Evaluating the Postoperative Patient.Academic emergency medicine : official journal of the Society for Academic Emergency Medicine · 2026Review
118 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionPain management after surgery continues to be suboptimal; there are several reasons including lack of translation of results from basic science studies and scientific clinical evidence into clinical praxis.
objectivesThis review presents and discusses basic science findings and scientific evidence generated within the last 2 decades in the field of acute postoperative pain.
methodsIn the first part of the review, we give an overview about studies that have investigated the pathophysiology of postoperative pain by using rodent models of incisional pain up to July 2016. The second focus of the review lies on treatment recommendations based on guidelines and clinical evidence, eg, by using the fourth edition of the "Acute Pain Management: Scientific Evidence" of the Australian and New Zealand College of Anaesthetists and Faculty of Pain Medicine.
resultsPreclinical studies in rodent models characterized responses of primary afferent nociceptors and dorsal horn neurons as one neural basis for pain behavior including resting pain, hyperalgesia, movement-evoked pain or anxiety- and depression-like behaviors after surgery. Furthermore, the role of certain receptors, mediators, and neurotransmitters involved in peripheral and central sensitization after incision were identified; many of these are very specific, relate to some modalities only, and are unique for incisional pain. Future treatment should focus on these targets to develop therapeutic agents that are effective for the treatment of postoperative pain as well as have few side effects. Furthermore, basic science findings translate well into results from clinical studies. Scientific evidence is able to point towards useful (and less useful) elements of multimodal analgesia able to reduce opioid consumption, improve pain management, and enhance recovery.
conclusionUnderstanding basic mechanisms of postoperative pain to identify effective treatment strategies may improve patients' outcome after surgery.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.