ArticlePain reports2016
Voluntary and evoked behavioral correlates in inflammatory pain conditions under different social housing conditions.
Article in Pain reports, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Pooled it
- The Intraplantar CFA Inflammatory Pain Model Incompletely Captures Pain Comorbidities Across Sexes.Journal of neuroscience research · 2026Article
- Group 2 innate lymphoid cells drive inhibitory synapse formation with lasting effects on learning and memory.Journal of neuroinflammation · 2025Article
- Peripheral inflammation is accompanied by cerebral hypoperfusion in mice.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Inflammatory pain resolution by mouse serum-derived small extracellular vesicles.Brain, behavior, and immunity · 2025Article
- Characterization of alterations in spontaneous behaviors in a rat model of neuropathic pain - new outcome measures for pain evaluation?Frontiers in behavioral neuroscience · 2025Article
- Inflammatory pain resolution by mouse serum-derived small extracellular vesicles.bioRxiv : the preprint server for biology · 2024Article
- PTZ-kindled rat model; evaluation of seizure, hippocampal EGR-1, and Rev-erbα gene regulation, behavioral analysis, and antioxidant capacity of Gum Arabic.Molecular biology reports · 2024Article
- Chronic Inflammation Disrupts Circadian Rhythms in Splenic CD4+ and CD8+ T Cells in Mice.Cells · 2024Article
- Advanced Dynamic Weight Bearing as an Observer-independent Measure of Hyperacute Hypersensitivity in Mice.Canadian journal of pain = Revue canadienne de la douleur · 2023Article
- Translational evaluation of gait behavior in rodent models of arthritic disorders with the CatWalk device - a narrative review.Frontiers in medicine · 2023Review
- Translating Outcomes from the Clinical Setting to Preclinical Models: Chronic Pain and Functionality in Chronic Musculoskeletal Pain.Pain medicine (Malden, Mass.) · 2022Article
- Organic anion transporter 1 is an HDAC4-regulated mediator of nociceptive hypersensitivity in mice.Nature communications · 2022Article
- Review
- Automated home-cage for the evaluation of innate non-reflexive pain behaviors in a mouse model of inflammatory pain.Scientific reports · 2021Article
- Deficit in voluntary wheel running in chronic inflammatory and neuropathic pain models in mice: Impact of sex and genotype.Behavioural brain research · 2021Article
- Loss of POMC-mediated antinociception contributes to painful diabetic neuropathy.Nature communications · 2021Article
- Investigating the Role of Ly6GFrontiers in pain research (Lausanne, Switzerland) · 2021Article
- Automated home-cage monitoring as a potential measure of sickness behaviors and pain-like behaviors in LPS-treated mice.PloS one · 2021Article
- A Low-Cost, Autonomous Gait Detection and Estimation System for Analyzing Gait Impairments in Mice.Journal of healthcare engineering · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Most preclinical pain models rely on short-duration stimulus-evoked hind paw measurements even though chronic pain is usually a day and night experience. Pain is a debilitating condition that influences the sociability and the ability for voluntary tasks, but the relevant behavioral readouts for these aspects are mostly underrepresented in the literature. Moreover, we lack standardization in most behavioral paradigms. Important aspects are herewith the combination and duration of particular behavioral tasks and the effects of social environment. We aimed at thoroughly investigating stimulus-evoked and voluntary behavioral parameters in the Complete Freund's Adjuvant model of unilateral hind paw inflammation in male mice. Moreover, we analyzed the impact of different social housing conditions. We used a portfolio of classical response measurements, detailed gait analysis, using 2 different measuring systems (Dynamic weight bearing and CatWalk), as well as observer-independent voluntary wheel running and homecage monitoring in a longitudinal time frame. The impact of grouped or isolated housing was investigated in all behavioral paradigms. We observed that unilateral hind paw inflammation provoked changes in several behaviors. Among these were wheel running activity and different homecage activity parameters. Stimulus-evoked hypersensitivity lasted much longer than gait abnormalities and decreased voluntary wheel running activity. Similar effects were monitored in both social housing conditions. This is the first longitudinal study providing detailed insights into various voluntary behavioral parameters related to pain in a unilateral inflammatory model. Stimulus-evoked behavioral changes lasted longer than changes in voluntary behavioral parameters, and the social environment hardly affects these changes.
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