Evidence map›Paper›PMID 29392160›Full record

ArticleJournal of medical imaging (Bellingham, Wash.)2018

Distinguishing benign and malignant breast tumors: preliminary comparison of kinetic modeling approaches using multi-institutional dynamic contrast-enhanced MRI data from the International Breast MR Consortium 6883 trial.

Anna G Sorace, Savannah C Partridge, Xia Li, Jack Virostko, Stephanie L Barnes, Daniel S Hippe, Wei Huang, Thomas E Yankeelov

Abstract read
In one paragraph

Article in Journal of medical imaging (Bellingham, Wash.), 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
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  16. Dynamic Contrast-enhanced MRI Detects Responses to Stroma-directed Therapy in Mouse Models of Pancreatic Ductal Adenocarcinoma.Clinical cancer research : an official journal of the American Association for Cancer Research · 2019
    Article
  17. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Anna G SoraceUniversity of Texas at Austin, Department of Diagnostic Medicine, Austin, Texas, United States.ORCID https://orcid.org/0000-0002-3640-3966
Savannah C PartridgeUniversity of Washington, Department of Radiology, Seattle, Washington, United States.ORCID https://orcid.org/0000-0001-6370-9111
Xia LiGE Global Research, Niskayuna, New York, United States.
Jack VirostkoUniversity of Texas at Austin, Department of Diagnostic Medicine, Austin, Texas, United States.
Stephanie L BarnesUniversity of Texas at Austin, Department of Biomedical Engineering, Austin, Texas, United States.
Daniel S HippeUniversity of Washington, Department of Radiology, Seattle, Washington, United States.ORCID https://orcid.org/0000-0003-2427-4404
Wei HuangOregon Health and Science University, Advanced Imaging Research Center, Portland, Oregon, United States.
Thomas E YankeelovUniversity of Texas at Austin, Department of Diagnostic Medicine, Austin, Texas, United States.

Funding

Understanding the origins of rapid recurrence of pancreatic cancer after resectionP30CA069533 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI Grace B Gill · 1997 to 2026
$60.5M
Targeted immunotherapy of breast cancer with central memory T cellsP50CA138293 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PORTER, PEGGY L. · 2010 to 2014
$11.0M
Quantitative MRI for Predicting Response of Breast Cancer to Neoadjuvant TherapyU01CA142565 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KARCZMAR, GREGORY S., NANDA, RITA · 2010 to 2019
$4.5M
Shutter-Speed Model DCE-MRI for Assessment of Response to Cancer TherapyU01CA154602 · NCI · OREGON HEALTH & SCIENCE UNIVERSITY · PI HUANG, WEI, RYAN, CHRISTOPHER WALTER · 2011 to 2015
$2.9M
Image Driven Multi-Scale Modeling to Predict Treatment Response in Breast CancerU01CA174706 · NCI · VANDERBILT UNIVERSITY · PI QUARANTA, VITO, YANKEELOV, THOMAS E · 2013 to 2018
$2.5M
Commercialization of the Shutter-Speed Model for Dynamic MRI in Cancer DiagnosisR44CA180425 · NCI · IMBIO, LLC · PI KEITH, LAUREN · 2013 to 2016
$1.8M
MR Diffusion Tensor Imaging for Detection and Characterization of Breast LesionsR01CA151326 · NCI · UNIVERSITY OF WASHINGTON · PI PARTRIDGE, SAVANNAH CORRINA · 2010 to 2014
$1.3M
NCI NIH HHS P30 CA069533NCI NIH HHS P50 CA138293NCI NIH HHS R01 CA151326NCI NIH HHS R44 CA180425NCI NIH HHS U01 CA142565NCI NIH HHS U01 CA154602NCI NIH HHS U01 CA174706
6 · The paper itself

Abstract

Comparative preliminary analysis of dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) data collected in the International Breast MR Consortium 6883 multicenter trial was performed to distinguish benign and malignant breast tumors. Prebiopsy DCE-MRI data from 45 patients with suspicious breast lesions were obtained. Semiquantitative mean signal-enhancement ratio ([Formula: see text]) was calculated for all lesions, and quantitative pharmacokinetic, parameters [Formula: see text], [Formula: see text], and [Formula: see text], were calculated for the subset with available [Formula: see text] maps ([Formula: see text]). Diagnostic performance was estimated for DCE-MRI parameters and compared to standard clinical MRI assessment. Quantitative and semiquantitative metrics discriminated benign and malignant lesions, with receiver operating characteristic area under the curve (AUC) values of 0.71, 0.70, and 0.82 for [Formula: see text], [Formula: see text], and [Formula: see text], respectively ([Formula: see text]). At equal 94% sensitivity, the specificity and positive predictive value of [Formula: see text] (53% and 63%, respectively) and

Indexed as

breast cancerdynamic contrast-enhanced MRIkepkinetic analysisKtranssignal-enhancement ratio

Identifiers

PMID29392160
PMCPMC5777541

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.