SynthesisBioMed research international2017
The Influence of Oral Dydrogesterone and Vaginal Progesterone on Threatened Abortion: A Systematic Review and Meta-Analysis.
Synthesis in BioMed research international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 4 syntheses or guidelines pooled it, 63 citations in OpenAlex.
- Progestogen therapy in threatened miscarriage and unexplained recurrent pregnancy loss: Recommendations by the Thai interest group.The journal of obstetrics and gynaecology research · 2025Guideline
- Progestogens in women with threatened miscarriage or recurrent miscarriage: A meta-analysis.Acta obstetricia et gynecologica Scandinavica · 2024Pooled it
- Efficacy and safety of Gushen Antai Pills combined with dydrogesterone in the treatment of threatened miscarriage: a systematic review and meta-analysis.Frontiers in pharmacology · 2023Pooled it
- Efficacy of progesterone on threatened miscarriage: an updated meta-analysis of randomized trials.Archives of gynecology and obstetrics · 2021Pooled it
- A randomised control trial on oral dydrogesteroneJournal of medicine and life · 2023Trial
- Efficacy of Jia Wei Shoutai Wan Combined With Dydrogesterone in the Treatment of Threatened Abortion Complicated With Endometrial Cavity Fluid: A Prospective, Single-Center, Randomized Controlled Trial.International journal of endocrinology · 2026Article
- Experiences of women with threatened abortion: a qualitative study of pregnant women and health providers in Iran.BMC health services research · 2025Article
- PERİDER-TJOD joint review on threatened abortion and guideline for its treatment.Turkish journal of obstetrics and gynecology · 2025Article
- Depressive and Anxiety Symptoms in Women with Threatened Abortion: A Case-Control Study.International journal of fertility & sterility · 2024Article
- Progesterone in Pregnancy: Evidence-Based Strategies to Reduce Miscarriage and Enhance Assisted Reproductive Technology.Medical science monitor : international medical journal of experimental and clinical research · 2024Article
- Threatened miscarriage and recurrent miscarriage: Expert opinions on progesterone therapy and treatment challenges.Turkish journal of obstetrics and gynecology · 2023Article
- The effects of dydrogesterone treatment on first-trimester aneuploidy screening markers and nuchal translucency in women with threatened miscarriage.Turkish journal of obstetrics and gynecology · 2023Article
- Prevention of Pregnancy Loss: Combining Progestogen Treatment and Psychological Support.Journal of clinical medicine · 2023Review
- Comparison of Dydrogesterone and GnRH-a Effects After Laparoscopic Surgery in Patients with Stage III and IV Endometriosis.International journal of general medicine · 2023Article
- Effects of hepatitis B virus infection and strategies for preventing mother-to-child transmission on maternal and fetal T-cell immunity.Frontiers in immunology · 2023Review
- Network pharmacological analysis and molecular docking of Huangqin-Baizhu herb pair in the treatment of threatened abortion.Medicine · 2022Article
- Evaluation of per Vaginal Bleeding With Different Drugs in Successful Pregnancy in Patients With Recurrent Pregnancy Loss: An Original Research.Journal of pharmacy & bioallied sciences · 2022Article
- Effects of Dydrogesterone Tablets Combined with Zishen Yutai Pills on Threatened Abortion in Early Pregnancy and Pregnancy Outcomes.Computational and mathematical methods in medicine · 2022Article
- Chinese Herbal Medicines Have Potentially Beneficial Effects on the Perinatal Outcomes of Pregnant Women.Frontiers in pharmacology · 2022Article
- A Comparative, Randomized Control Trial in Patients of Per Vaginal Bleeding Comparing Efficacy of Oral Dydrogesterone Versus Vaginal Progesterone in Successful Pregnancy Outcome for Patients with Recurrent Pregnancy Loss.Journal of obstetrics and gynaecology of India · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo conduct systematic analyses to evaluate the efficacy of progesterone therapy for the prevention of miscarriages in pregnant women experiencing threatened abortion.
methodsIn November 2016, we performed a systematic literature search and identified 51 articles in PubMed, Embase, and Cochrane databases. We identified nine randomized trials that included 913 pregnant women (including 322 treated with oral dydrogesterone, 213 treated with vaginal progesterone, and 378 control subjects) who met the selection criteria.
resultsThe incidence of miscarriage was significantly lower in the total progesterone group than in the control group (13.0% versus 21.7%; odds ratio, 0.53; 95% confidence interval (CI), 0.36 to 0.78;
conclusionProgesterone therapy, especially oral dydrogesterone, can effectively prevent miscarriage in pregnant women experiencing threatened abortion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.