ReviewAging and disease2018
A Comprehensive Review of Non-Steroidal Anti-Inflammatory Drug Use in The Elderly.
Review in Aging and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 341 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Brief Patient Educational Video to Reduce Potentially Harmful Over-the-counter Nonsteroidal Anti-inflammatory Drug (NSAID) Use
Pilot Study Using Topical Cannabidiol (CBD) to Manage Osteoarthritic Knee Pain
Who cites it
341 citing papers in PubMed, 5 syntheses or guidelines pooled it, 885 citations in OpenAlex.
- Analgesic drug efficacy in mouse postoperative pain: a systematic review and meta-analysis.Lab animal · 2026Pooled it
- Efficacy and safety of Chinese herbal compounds for lumbar disc herniation: a systematic review of randomized controlled trials.Systematic reviews · 2025Pooled it
- Pooled it
- The 2023 WSES guidelines on the management of trauma in elderly and frail patients.World journal of emergency surgery : WJES · 2024Guideline
- Pooled it
- Long-term home-based physical exercise, pain, and use of pain medication over a year after hip fracture - A secondary analysis of a randomised controlled trial.Clinical rehabilitation · 2026Trial
- Efficacy and Safety Comparison of Ulinastatin Versus Flurbiprofen Axetil for Preemptive Analgesia in Reducing Opioid Burden After Total Knee Arthroplasty: A Randomized Controlled Trial.Journal of pain research · 2025Trial
- Prevalence and Sociodemographic Variation of Allergic Diseases in Australia: Findings From the Australian National Health Survey.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2026Article
- Anti-Inflammatory Activity of Cotula cinerea Essential Oil: Integrated Chemical, In Vivo, Histological, and Computational Evaluation.Chemistry & biodiversity · 2026Article
- Pharmacological management of knee and hip osteoarthritis stratified by oral nonsteroidal anti-inflammatory drugs safety status.Journal of bone and mineral metabolism · 2026Article
- OTC Medication Risk Literacy, Confidence, and Safety Behaviours Among Romanian Adults: A Cross-Sectional Scenario-Based Assessment.Healthcare (Basel, Switzerland) · 2026Article
- Expert consensus on the application of nonsteroidal anti-inflammatory drugs for perioperative analgesia.Journal of anesthesia and translational medicine · 2026Article
- Acute migraine treatments in patients above age 65.Headache · 2026Review
- Low-Dose Radiation Therapy for Osteoarthritis: Analysis of Preliminary Outcomes at Scripps Clinic.Advances in radiation oncology · 2026Article
- Reorganization of Innate Immune Cell Lipid Profiles by Bioinspired Meroterpenoids to Limit Inflammation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Dual protective role of curcumin- encapsulated chitosan nanoparticles against gastric and neural injury in a rat model of gut-brain axis dysfunction: a histological and biochemical study.Naunyn-Schmiedeberg's archives of pharmacology · 2026Article
- Crosslinking-Dependent Design of Hyaluronic Acid Matrices for Enhanced Bioadhesion and Cellular Response.Pharmaceutics · 2026Article
- Efficacy and Safety of Traditional Chinese Medicine Exercise Versus Oral Medication in the Treatment of Neck Pain: Study Protocol for a Systematic Review and Meta-Analysis.JMIR research protocols · 2026Article
- Geriatric Migraine, Geroscience, and Sustainable Development Goals: Bridging Clinical Complexity and Public Health Priorities.Journal of clinical medicine · 2026Review
- Gastric perforation at the extremes of age: a comparative case report of NSAID-associated high-grade dysplasia versus methamphetamine-induced ischemic perforation.International journal of emergency medicine · 2026Article
281 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
NSAIDs, non-steroidal anti-inflammatory drugs, are one of the most commonly prescribed pain medications. It is a highly effective drug class for pain and inflammation; however, NSAIDs are known for multiple adverse effects, including gastrointestinal bleeding, cardiovascular side effects, and NSAID induced nephrotoxicity. As our society ages, it is crucial to have comprehensive knowledge of this class of medication in the elderly population. Therefore, we reviewed the pharmacodynamics and pharmacokinetics, current guidelines for NSAIDs use, adverse effect profile, and drug interaction of NSAIDs and commonly used medications in the elderly.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.