Evidence map›Paper›PMID 29392086›Full record

ArticleAging and disease2018

Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using

Fangyu Peng, Fang Xie, Otto Muzik

Open access · goldAbstract read
In one paragraph

Article in Aging and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Inhibitory effect of standardizedJournal of traditional and complementary medicine · 2026
    Article
  2. Article
  3. Copper homeostasis and cuproptosis in Alzheimer's disease (Review).International journal of molecular medicine · 2025
    Review
  4. Article
  5. Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Rejuvenating the Aging Heart by Enhancing the Expression of theInternational journal of molecular sciences · 2021
    Article
  11. Mouse models of sarcopenia: classification and evaluation.Journal of cachexia, sarcopenia and muscle · 2021
    Review
  12. Review
  13. Article
  14. Article
  15. Review
  16. Insights into Trace Metal Metabolism in Health and Disease from PET: "PET Metallomics".Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2018
    Review
  17. Article
  18. Copper-64: a real theranostic agent.Drug design, development and therapy · 2018
    Review
  19. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Fangyu Peng1Department of Radiology, and.
Fang Xie1Department of Radiology, and.
Otto Muzik3Department of Pediatrics and.
Pediatrics and Genetics · USSouthwestern Medical Center

Funding

RESEARCH RESOURCE IN RADIONUCLIDE RESEARCHR24CA086307 · NCI · WASHINGTON UNIVERSITY · PI WELCH, MICHAEL J. · 1999 to 2009
$8.4M
Noninvasive Assessment of Traumatic Brain Injury with PET using 64CuCl2R21NS074394 · NINDS · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, FANGYU · 2011 to 2012
$455k
Altered Copper Metabolism as Theranostic Biomarker in Alzheimer's DiseaseR21AG047953 · NIA · UT SOUTHWESTERN MEDICAL CENTER · PI PENG, FANGYU · 2014 to 2015
$450k
NCI NIH HHS R24 CA086307NIA NIH HHS R21 AG047953NINDS NIH HHS R21 NS074394
6 · The paper itself

Abstract

Brain aging is associated with changes of various metabolic pathways. Copper is required for brain development and function, but little is known about changes in copper metabolism during brain aging. The objective of this study was to investigate alteration of copper fluxes in the aging mouse brain with positron emission tomography/computed tomography using

Indexed as

Alzheimer’s diseasebrain agingcopper-64 chloridecopper fluxesglucose metabolismPositron emission tomography

Identifiers

PMID29392086
PMCPMC5772849
OpenAlexW2784493975

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.