ArticleAging and disease2018
Causes of Death in Chinese Patients with Multiple System Atrophy.
Article in Aging and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Low level of serum total cholesterol predicts mortality in early-stage multiple system atrophy: a prospective-cohort study.Frontiers in nutrition · 2025Article
- Esophageal Dysmotility in Multiple System Atrophy: A Retrospective Cross-Sectional Study.Journal of clinical medicine · 2024Article
- The comorbidity profiles and medication issues of patients with multiple system atrophy: a systematic cross-sectional analysis.Journal of neurology · 2024Article
- Sex-related differences in the clinical presentation of multiple system atrophy.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Review
- Effect of long-term transcutaneous auricular vagus nerve stimulation in multiple system atrophy-cerebellar subtype: a case report.Frontiers in neuroscience · 2024Article
- Rates of change of pons and middle cerebellar peduncle diameters are diagnostic of multiple system atrophy of the cerebellar type.Brain communications · 2024Article
- Longitudinal evolution of sleep disturbances in early multiple system atrophy: a 2-year prospective cohort study.BMC medicine · 2023Article
- Modified version of unified multiple system atrophy rating scale for remote video-based assessments.NPJ Parkinson's disease · 2023Article
- Deterioration of Cough, Respiratory, and Vocal Cord Functions in Patients with Multiple System Atrophy.Neurology international · 2023Article
- Multiple system atrophy.Practical neurology · 2023Review
- Diagnostic utility of movement disorder society criteria for multiple system atrophy.Frontiers in aging neuroscience · 2023Article
- Tracheostomy is associated with increased survival in Multiple System Atrophy patients with stridor.European journal of neurology · 2022Article
- Relationship Between Pneumonia and Dysphagia in Patients With Multiple System Atrophy.Frontiers in neurology · 2022Article
- Article
- Non-aneurysmal Subarachnoid Hemorrhaging: A Rare Cause of Death in a Patient with Multiple System Atrophy.Internal medicine (Tokyo, Japan) · 2019Article
- MicroRNAs Dysregulation and Metabolism in Multiple System Atrophy.Frontiers in neuroscience · 2019Review
- High Resolution Manofluorographic Study in Patients With Multiple System Atrophy: Possible Early Detection of Upper Esophageal Sphincter and Proximal Esophageal Abnormality.Frontiers in medicine · 2018Article
- Epidemiology of atypical parkinsonian syndromes.Tzu chi medical journalReview
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The objective of this study was to explore the causes of death in Chinese patients with multiple system atrophy (MSA) as well as differences in the cause of death according to sex, subtype, disease onset, and whether the disease was accompanied by nocturnal stridor. A total of 131 MSA patients were enrolled and followed up once every year until their deaths. Clinical information was collected by neurologists, and the cause of death of the MSA patients was obtained from the patients' relatives or caregivers. The current study included 62 MSA with predominant parkinsonism (MSA-P) and 69 MSA with predominant cerebellar ataxia (MSA-C) patients. Median survival time from disease onset to death of the MSA patients was 5.59 years. The most common cause of death was respiratory infection (65.6%). The second most common cause of death was sudden death (14.5%). Other causes included nutritional disorder due to dysphagia (9.2%), urinary tract infection (3.1%), suicide (2.3%), choking (1.5%), cerebrovascular accident (1.5%), myocardial infarction (1.5%), and lymphoma (0.8%). We found that sudden death was more likely to occur in patients with nocturnal stridor than in those without (P<0.001). There were no significant differences in the cause of death according to subtype, sex, or onset symptoms (autonomic failure or motor symptoms). Sudden death is a relatively common cause of death in MSA patients, second only to respiratory infection, especially in patients with nocturnal stridor. The information provided by our study may help to provide better medical care to MSA patients.
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