Evidence map›Paper›PMID 29392081›Full record

ArticleAging and disease2018

Trefoil Factor 3, Cholinesterase and Homocysteine: Potential Predictors for Parkinson's Disease Dementia and Vascular Parkinsonism Dementia in Advanced Stage.

Jing Zou, Zhigang Chen, Caiqian Liang, Yongmei Fu, Xiaobo Wei, Jianjun Lu, Mengqiu Pan, Yue Guo, Xinxue Liao, Huifang Xie and 5 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging and disease, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 4 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 4 syntheses or guidelines pooled it, 49 citations in OpenAlex.

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  12. Homocysteine fibrillar assemblies display cross-talk with Alzheimer's disease β-amyloid polypeptide.Proceedings of the National Academy of Sciences of the United States of America · 2021
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  19. Plasma proteomic signatures predict dementia and cognitive impairment.Alzheimer's & dementia (New York, N. Y.) · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 6 institutions in 3 countries.

Jing Zou *1Department of Neurology, and.
Zhigang Chen *1Department of Neurology, and.
Caiqian Liang *2Department of Emergency, The Third Affiliated Hospital of Sun Yat-Sen University, China.
Yongmei Fu2Department of Emergency, The Third Affiliated Hospital of Sun Yat-Sen University, China.
Xiaobo Wei1Department of Neurology, and.
Jianjun Lu3Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.
Mengqiu Pan3Department of Neurology, Guangdong 999 Brain Hospital, Guangzhou, China.
Yue Guo4Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, China.
Xinxue Liao4Department of Cardiology, The First Affiliated Hospital of Sun Yat-Sen University, China.
Huifang Xie5Department of Neurology, Zhujiang Hospital, Southern Medical University, China.
Duobin Wu5Department of Neurology, Zhujiang Hospital, Southern Medical University, China.
Min Li6School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China.
Lihui Liang7Department of Geriatric Medicine, Hunan Provincial People's Hospital, Changsha, Hunan, China.
Penghua Wang8Department of Microbiology & Immunology, School of Medicine, New York Medical College, NY 10595, USA.
Qing Wang1Department of Neurology, and.
Guangdong 999 Brain Hospital · CNSun Yat-sen University · CNHong Kong Baptist University · HKNew York Medical College · USSouthern Medical University · CNZhujiang Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Trefoil factor 3 (TFF3), cholinesterase activity (ChE activity) and homocysteine (Hcy) play critical roles in modulating recognition, learning and memory in neurodegenerative diseases, such as Parkinson's disease dementia (PDD) and vascular parkinsonism with dementia (VPD). However, whether they can be used as reliable predictors to evaluate the severity and progression of PDD and VPD remains largely unknown.

methodsWe performed a cross-sectional study that included 92 patients with PDD, 82 patients with VPD and 80 healthy controls. Serum levels of TFF3, ChE activity and Hcy were measured. Several scales were used to rate the severity of PDD and VPD. Receivers operating characteristic (ROC) curves were applied to map the diagnostic accuracy of PDD and VPD patients compared to healthy subjects.

resultsCompared with healthy subjects, the serum levels of TFF3 and ChE activity were lower, while Hcy was higher in the PDD and VPD patients. These findings were especially prominent in male patients. The three biomarkers displayed differences between PDD and VPD sub-groups based on genders and UPDRS (III) scores' distribution. Interestingly, these increased serum Hcy levels were significantly and inversely correlated with decreased TFF3/ChE activity levels. There were significant correlations between TFF3/ChE activity/Hcy levels and PDD/VPD severities, including motor dysfunction, declining cognition and mood/gastrointestinal symptoms. Additionally, ROC curves for the combination of TFF3, ChE activity and Hcy showed potential diagnostic value in discriminating PDD and VPD patients from healthy controls.

conclusionsOur findings suggest that serum TFF3, ChE activity and Hcy levels may underlie the pathophysiological mechanisms of PDD and VPD. As the race to find biomarkers or predictors for these diseases intensifies, a better understanding of the roles of TFF3, ChE activity and Hcy may yield insights into the pathogenesis of PDD and VPD.

Indexed as

ChE activityHcyParkinson disease dementiapathogenesisTFF3vascular parkinsonism dementia

Identifiers

PMID29392081
PMCPMC5772858
OpenAlexW2785233760

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.