ArticleTurkish archives of otorhinolaryngology2016
Pharyngocutaneous Fistula after Total Laryngectomy: Risk Factors with Emphasis on Previous Radiotherapy and Heavy Smoking.
Article in Turkish archives of otorhinolaryngology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effect of possible risk factors for pharyngocutaneous fistula after total laryngectomy of laryngeal carcinomas and surgical wound infection: A meta-analysis.International wound journal · 2023Pooled it
- Risk factors of pharyngocutaneous fistula after total laryngectomy: a systematic review and meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2020Pooled it
- Automatic versus Manual Suturing in Total Laryngectomy: Fistula Incidence, Margin Status, and Operative Time.International archives of otorhinolaryngology · 2026Article
- Comparison of multivariable logistic regression and machine learning models for predicting pharyngocutaneous fistula after surgery for laryngeal and hypopharyngeal carcinoma.Frontiers in surgery · 2026Article
- The use of Montgomery salivary bypass tubes and pharyngocutaneous fistula following salvage laryngectomy.World journal of otorhinolaryngology - head and neck surgery · 2024Article
- Evaluation of the Incidence of Pharyngocutaneous Fistula after Total Laryngectomy.Iranian journal of otorhinolaryngology · 2023Article
- Meta-analysis of risk factors associated with pharyngocutaneous fistulas following total laryngectomy.American journal of translational research · 2023Review
- Pharyngocutaneous Fistula Following Primary Total Laryngectomy: a Meta-analysis.Indian journal of surgical oncology · 2022Review
- Review
- Total Laryngectomy: A Review of Surgical Techniques.Cureus · 2021Review
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveIn this retrospective cohort study, we aimed to determine the incidence of pharyngocutaneous fistula (PCF) after total laryngectomy (TL) and to define the possible predictors for PCF formation.
methodsThe medical records of 198 patients with laryngeal squamous cell carcinoma who underwent TL were reviewed. After the exclusion of patients with history of free flap reconstruction, previous laryngeal surgery, and previous radiotherapy (RT) for other primary cancers, the risk factors for PCF were analyzed in 183 patients who were included in the study.
resultsThe overall incidence of PCF was 20.2%. A history of heavy smoking and previous RT were detected as independent risk factors in both univariate (p=0.004 and p=0.007, respectively) and multivariate (p=0.005) analyses. Preoperative tracheotomy (PT) longer than 14 days was a risk factor for PCF among patients with PT in the univariate analysis (p=0.031). Overall three- and five-year survival rates were statistically indifferent between the PCF and non-PCF groups (p>0.05). However, the overall five-year survival rate was lesser in the persistent PCF group (47%) than in the non-persistent PCF group (83%) (p=0.038).
conclusionHeavy smoking and previous RT are independent risk factors for PCF, and the persistence of PCF decreases survival rates. Preventable measures should be taken to decrease the incidence and persistence of this complication of TL in the management of patients with possible risk factors.
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