Evidence map›Paper›PMID 29391923›Full record

ArticleOxidative medicine and cellular longevity2017

Roles of Endoplasmic Reticulum Stress in NECA-Induced Cardioprotection against Ischemia/Reperfusion Injury.

Fengmei Xing, Hui Han, Yonggui He, Yidong Zhang, Liwei Jing, Zhelong Xu, Jinkun Xi

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Fengmei XingCollege of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063000, China.
Hui HanCollege of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063000, China.
Yonggui HeHeart Institute, North China University of Science and Technology, Tangshan 063000, China.
Yidong ZhangHeart Institute, North China University of Science and Technology, Tangshan 063000, China.
Liwei JingCollege of Nursing and Rehabilitation, North China University of Science and Technology, Tangshan 063000, China.
Zhelong XuHeart Institute, North China University of Science and Technology, Tangshan 063000, China.
Jinkun XiHeart Institute, North China University of Science and Technology, Tangshan 063000, China.ORCID 0000-0002-5220-1192
North China University of Science and Technology · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate whether the nonselective A2 adenosine receptor agonist NECA induces cardioprotection against myocardial ischemia/reperfusion (I/R) injury via glycogen synthase kinase 3 METHODS AND

resultsH9c2 cells were exposed to H

conclusionThese data suggest that NECA prevents the mPTP opening through inactivation of GSK-3

Indexed as

Adenosine-5'-(N-ethylcarboxamide)AnimalsCardiotonic AgentsEndoplasmic Reticulum StressGlycogen Synthase Kinase 3 betaHydrogen PeroxideMaleMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition PoreMyocardial Reperfusion InjuryRatsSignal TransductionAdenosine-5'-(N-ethylcarboxamide)Cardiotonic AgentsGlycogen Synthase Kinase 3 betaGsk3b protein, ratHydrogen PeroxideMitochondrial Membrane Transport ProteinsMitochondrial Permeability Transition Pore

Identifiers

PMID29391923
PMCPMC5748120
OpenAlexW2773709046

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.