Evidence map›Paper›PMID 29391797›Full record

ArticleInternational journal of nanomedicine2018

Dose reduction of bone morphogenetic protein-2 for bone regeneration using a delivery system based on lyophilization with trehalose.

Xiaochen Zhang, Quan Yu, Yan-An Wang, Jun Zhao

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 25 citations in OpenAlex.

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  8. Anodic TiONanomaterials (Basel, Switzerland) · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xiaochen Zhang *Department of Oral and Maxillofacial-Head and Neck Oncology.
Quan Yu *Department of Orthodontics, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
Yan-An WangDepartment of Oral and Maxillofacial-Head and Neck Oncology.
Jun ZhaoDepartment of Orthodontics, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China.
National Medical Research Center of Dentistry and Maxillofacial Surgery · RUShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionTo induce sufficient new bone formation, high doses of bone morphogenetic protein-2 (BMP-2) are applied in regenerative medicine that often induce serious side effects. Therefore, improved treatment strategies are required. Here, we investigate whether the delivery of BMP-2 lyophilized in the presence of trehalose reduced the dose of BMP-2 required for bone regeneration. MATERIALS AND

methodsA new growth factor delivery system was fabricated using BMP-2-loaded TiO

resultsCompared with absorbed BMP-2-loaded TiO

conclusionOur findings indicate that delivery of BMP-2 lyophilized with trehalose may be a promising method to reduce the dose of BMP-2 and avoid the associated side effects.

Indexed as

Drug Delivery SystemsFreeze DryingAnimalsBone Morphogenetic Protein 2Bone RegenerationCell DifferentiationCell ProliferationDose-Response Relationship, DrugDrug LiberationMaleMesenchymal Stem CellsNanotubesOsteogenesisRats, Inbred F344TitaniumTrehaloseBone Morphogenetic Protein 2TitaniumTrehaloseBMP-2bone morphogenetic protein-2delivery systemdose reductionlyophilizationregenerative medicinesurface modificationTiO2 nanotubestrehalose

Identifiers

PMID29391797
PMCPMC5769568
OpenAlexW2783350834

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.