Evidence map›Paper›PMID 29391796›Full record

ArticleInternational journal of nanomedicine2018

In vivo therapeutic efficacy of TNFα silencing by folate-PEG-chitosan-DEAE/siRNA nanoparticles in arthritic mice.

Qin Shi, Elsa-Patricia Rondon-Cavanzo, Isadora Pfeifer Dalla Picola, Marcio José Tiera, Xiaoling Zhang, Kerong Dai, Houda Abir Benabdoune, Mohamed Benderdour, Julio Cesar Fernandes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
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  9. RNA Interference Ex Vivo.Methods in molecular biology (Clifton, N.J.) · 2024
    Article
  10. Review
  11. Arthritic Microenvironment-Dictated Fate Decisions for Stem Cells in Cartilage Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Nanoparticles and cytokine response.Frontiers in bioengineering and biotechnology · 2023
    Review
  20. Role of macrophage polarization in osteoarthritis (Review).Experimental and therapeutic medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Qin ShiOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Elsa-Patricia Rondon-CavanzoOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Isadora Pfeifer Dalla PicolaOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Marcio José TieraDepartment of Chemistry and Environmental Sciences, UNESP-São Paulo State University, São José do Rio Preto, Brazil.
Xiaoling ZhangOrthopedic Cellular and Molecular Biology Laboratories, Institute of Health Sciences, Chinese Academy of Sciences and Shanghai Jiao Tong University School of Medicine, Shanghai.
Kerong DaiDepartment of Orthopedics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Houda Abir BenabdouneOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Mohamed BenderdourOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Julio Cesar FernandesOrthopedic Research Laboratory, Hôpital du Sacré-Coeur de Montréal, Université de Montréal, Montréal, QC, Canada.
Université de Montréal · CAHôpital du Sacré-Cœur de Montréal · CAShanghai Jiao Tong University · CNShanghai Ninth People's Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTumor necrosis factor-alpha (TNFα), a pro-inflammatory cytokine, has been shown to play a role in the pathophysiology of rheumatoid arthritis. Silencing TNFα expression with small interfering RNA (siRNA) is a promising approach to treatment of the condition.

methodsTowards this end, our team has developed a modified chitosan (CH) nanocarrier, deploying folic acid, diethylethylamine (DEAE) and polyethylene glycol (PEG) (folate-PEG-CH-DEAE

resultsWe demonstrated that folate-PEG-CH-DEAE

conclusionThe results indicate that folate-PEG-CH-DEAE

Indexed as

Alkaline PhosphataseAnimalsArthritis, ExperimentalBiomarkersBone ResorptionCartilageCell SurvivalChitosanDisease ProgressionFemaleFolic AcidGene Transfer TechniquesInflammation MediatorsJointsMice, Inbred DBANanoparticlesAlkaline PhosphataseBiomarkersChitosandiethylethylamine-chitosanFolic AcidInflammation MediatorsOsteocalcinPeptide FragmentsPolyethylene GlycolsProcollagenprocollagen Type I N-terminal peptideRNA, Small InterferingTartrate-Resistant Acid PhosphataseTumor Necrosis Factor-alphaarthritischitosaninflammationnanoparticlessiRNATNFα

Identifiers

PMID29391796
PMCPMC5769564
OpenAlexW2783947661

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.