Evidence map›Paper›PMID 29391794›Full record

ArticleInternational journal of nanomedicine2018

Micelle-templated, poly(lactic-

Gauri M Nabar, Kalpesh D Mahajan, Mark A Calhoun, Anthony D Duong, Matthew S Souva, Jihong Xu, Catherine Czeisler, Vinay K Puduvalli, José Javier Otero, Barbara E Wyslouzil and 1 more

Open access · goldAbstract read
In one paragraph

Article in International journal of nanomedicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Nrf2 Plays a Key Role in Erythropoiesis during Aging.Antioxidants (Basel, Switzerland) · 2024
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Systemic Review of Biodegradable Nanomaterials in Nanomedicine.Nanomaterials (Basel, Switzerland) · 2020
    Review
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Gauri M NabarWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Kalpesh D MahajanWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Mark A CalhounDepartment of Biomedical Engineering.
Anthony D DuongWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Matthew S SouvaWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Jihong XuDivision of Neuro-oncology, College of Medicine, The Ohio State University Comprehensive Cancer Center.
Catherine CzeislerDepartment of Pathology and the Neurological Research Institute, College of Medicine.
Vinay K PuduvalliDivision of Neuro-oncology, College of Medicine, The Ohio State University Comprehensive Cancer Center.
José Javier OteroDepartment of Pathology and the Neurological Research Institute, College of Medicine.
Barbara E WyslouzilWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Jessica O WinterWilliam G Lowrie Department of Chemical and Biomolecular Engineering.
Williams & Associates · USCenter for Neuro-Oncology · USNeurological Research Institute · US

Funding

Translational Therapeutics Research Program (TT)P30CA016058 · NCI · OHIO STATE UNIVERSITY · PI Jennifer A. Woyach · 1985 to 2026
$132.3M
Patient Oriented Research Program in Neuro-oncologyK24CA160777 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI PUDUVALLI, VINAY K · 2012 to 2015
$580k
NCI NIH HHS K24 CA160777NCI NIH HHS P30 CA016058
6 · The paper itself

Abstract

purposePoly(lactic-

methodsHere, we present a bottom-up synthesis method yielding PLGA/block copolymer hybrids (ie, "PolyDots"), consisting of hydrophobic PLGA chains entrapped within self-assembling poly(styrene-

resultsPolyDots exhibit average diameters <50 nm and lower polydispersity than conventional PLGA NPs. Drug encapsulation efficiencies of PolyDots match conventional PLGA NPs (ie, ~30%) and are greater than those obtained from PS-

conclusionEncapsulation of PLGA within micelles provides a bottom-up route for the synthesis of sub-100 nm PLGA-based nanocarriers with enhanced stability and drug-loading capacity, and tunable drug release, suitable for potential clinical applications.

Indexed as

Cell Line, TumorDexamethasoneDrug CarriersDrug Delivery SystemsDrug LiberationEmulsionsEndocytosisGliomaHumansHydrophobic and Hydrophilic InteractionsLactic AcidMicellesMicroscopy, Electron, TransmissionNanoparticlesParticle SizePolyethylene GlycolsDexamethasoneDrug CarriersEmulsionsLactic AcidMicellesPolyethylene GlycolsPolyglycolic AcidPolylactic Acid-Polyglycolic Acid Copolymerpolystyrene-b-poly(ethylene oxide)Polystyrenesblock copolymerdrug deliveryelectrospraygliomahydrophobic drugmicellesnanoparticlesPLGA

Identifiers

PMID29391794
PMCPMC5768187
OpenAlexW2783975917

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.