Evidence map›Paper›PMID 29391754›Full record

ReviewWorld journal of gastroenterology2018

Use of direct-acting antiviral agents in hepatitis C virus-infected liver transplant candidates.

Chiranjeevi Gadiparthi, George Cholankeril, Brandon J Perumpail, Eric R Yoo, Sanjaya K Satapathy, Satheesh Nair, Aijaz Ahmed

Abstract readReview
In one paragraph

Review in World journal of gastroenterology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Perioperative Evaluation and Management of Patients With Cirrhosis: Risk Assessment, Surgical Outcomes, and Future Directions.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2020
    Review
  4. Review
  5. Review
  6. Article
  7. Article
  8. Review
  9. The impact of direct-acting antiviral agents on liver and kidney transplant costs and outcomes.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Chiranjeevi GadiparthiDivision of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, Memphis, TN 38104, United States.
George CholankerilDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94304, United States.
Brandon J PerumpailDrexel University College of Medicine, Philadelphia, PA 19129, United States.
Eric R YooDepartment of Medicine, Santa Clara Valley Medical Center, San Jose, CA 95128, United States.
Sanjaya K SatapathyDivision of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, Memphis, TN 38104, United States.
Satheesh NairDivision of Gastroenterology and Hepatology, University of Tennessee Health Sciences Center, Memphis, TN 38104, United States.
Aijaz AhmedDivision of Gastroenterology and Hepatology, Stanford University School of Medicine, Stanford, CA 94304, United States. aijazahmed@stanford.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since the advent of direct acting antiviral (DAA) agents, chronic hepatitis C virus (HCV) treatment has evolved at a rapid pace. In contrast to prior regimen involving ribavirin and pegylated interferon, these newer agents are highly effective, well-tolerated, have shorter course of therapy and safer essentially in all HCV patients including those with advanced liver disease and following liver transplantation. Clinicians caring for HCV-infected patients on the liver transplant (LT) waitlist are often faced with a dilemma whether to treat HCV infection before or after liver transplantation. Sustained virological response (SVR) rates following HCV treatment may improve hepatic function sufficiently enough to negate the need for LT in certain patients. On the other hand, the decrease in MELD without improvement in quality of life in certain patients may lead to delay or dropout from potentially curative LT surgery list. In this context, our review focuses on the approach to and optimal timing of DAA-based treatment of HCV infection in LT candidates in the peri-transplant period.

Indexed as

Liver TransplantationAntiviral AgentsCost-Benefit AnalysisDrug Therapy, CombinationEnd Stage Liver DiseaseHepacivirusHepatitis C, ChronicHumansInterferon-alphaPolyethylene GlycolsPostoperative CarePreoperative CareRecombinant ProteinsRecurrenceSeverity of Illness IndexSustained Virologic ResponseAntiviral AgentsInterferon-alphapeginterferon alfa-2aPolyethylene GlycolsRecombinant ProteinsDirect-acting antiviral therapyHepatitis C virusLiver transplantationPurgatory Model for End-stage liver diseaseSustained virological response

Identifiers

PMID29391754
PMCPMC5776393

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.