ArticleScientific reports2018
Evaluating upper limb impairments in multiple sclerosis by exposure to different mechanical environments.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
39 citing papers in PubMed, 1 synthesis or guideline pooled it, 91 citations in OpenAlex.
- A Systematic Review of EMG Applications for the Characterization of Forearm and Hand Muscle Activity during Activities of Daily Living: Results, Challenges, and Open Issues.Sensors (Basel, Switzerland) · 2021Pooled it
- A randomized controlled trial on the effects induced by robot-assisted and usual-care rehabilitation on upper limb muscle synergies in post-stroke subjects.Scientific reports · 2021Trial
- Effects of robot therapy on upper body kinematics and arm function in persons post stroke: a pilot randomized controlled trial.Journal of neuroengineering and rehabilitation · 2020Trial
- Reliability, validity and discriminant ability of the instrumental indices provided by a novel planar robotic device for upper limb rehabilitation.Journal of neuroengineering and rehabilitation · 2018Trial
- Age-dependent synergistic control of sit-to-stand motion.European journal of applied physiology · 2026Article
- Increased exertion variability is linked to disruptions in effort assessment in multiple sclerosis.Multiple sclerosis (Houndmills, Basingstoke, England) · 2026Article
- Task complexity amplifies spatial asymmetry of muscle synergy plasticity in chronic stroke survivors.Journal of neuroengineering and rehabilitation · 2026Article
- Muscle coordination strategies during Functional Reach across multiple directions in healthy individuals.European journal of applied physiology · 2026Article
- Predicting multiple sclerosis disease progression and outcomes with machine learning and MRI-based biomarkers: a review.Journal of neurology · 2024Review
- Diagnostic uncertainty of steroid-modified Marburg's variant of multiple sclerosis even at autopsy: A case suggesting lymphoma and related myelin loss.eNeurologicalSci · 2024Article
- The effect of gravity on hand spatio-temporal kinematic features during functional movements.PloS one · 2024Article
- Muscle synergies for evaluating upper limb in clinical applications: A systematic review.Heliyon · 2023Review
- Metabolic costs of walking and arm reaching in persons with mild multiple sclerosis.Journal of neurophysiology · 2023Article
- Microglia depletion as a therapeutic strategy: friend or foe in multiple sclerosis models?Neural regeneration research · 2023Review
- The Design, Development, and Testing of a Virtual Reality Device for Upper Limb Training in People With Multiple Sclerosis: Single-Center Feasibility Study.JMIR serious games · 2022Article
- Effects of Cognitive Exercise Therapy on Upper Extremity Sensorimotor Function and Activities of Daily Living in Patients with Chronic Stroke: A Randomized Controlled Trial.Healthcare (Basel, Switzerland) · 2022Article
- Personalized prediction of rehabilitation outcomes in multiple sclerosis: a proof-of-concept using clinical data, digital health metrics, and machine learning.Medical & biological engineering & computing · 2022Article
- Assessing visually guided reaching in people with multiple sclerosis with and without self-reported upper limb impairment.PloS one · 2022Article
- Upper Limb Sensory-Motor Control During Exposure to Different Mechanical Environments in Multiple Sclerosis Subjects With No Clinical Disability.Frontiers in neurorobotics · 2022Article
- Therapeutic effect of combination vitamin D3 and siponimod on remyelination and modulate microglia activation in cuprizone mouse model of multiple sclerosis.Frontiers in behavioral neuroscience · 2022Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Multiple sclerosis is a chronic, autoimmune and neurodegenerative disease affecting multiple functional systems and resulting in motor impairments associated with muscle weakness and lack of movement coordination. We quantified upper limb motor deficits with a robot-based assessment including behavioral and muscle synergy analysis in 11 multiple sclerosis subjects with mild to moderate upper limb impairment (9 female; 50 ± 10 years) compared to 11 age- and gender- matched controls (9 female; 50 ± 9 years). All subjects performed planar reaching tasks by moving their upper limb or applying force while grasping the handle of a robotic manipulandum that generated four different environments: free space, assistive or resistive forces, and rigid constraint. We recorded the activity of 15 upper body muscles. Multiple sclerosis subjects generated irregular trajectories. While activities in isolated arm muscles appeared generally normal, shoulder muscle coordination with arm motions was impaired and there was a marked co-activation of the biceps and triceps in extension movements. Systematic differences in timing and organization of muscle synergies have also been observed. This study supports the definition of new biomarkers and rehabilitative treatments for improving upper limb motor coordination in multiple sclerosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.