ArticleScientific reports2018
X-Ray Dark-field Imaging to Depict Acute Lung Inflammation in Mice.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed.
- Beam-hardening correction in clinical x-ray dark-field chest radiography using deep-learning-based bone segmentation.Medical physics · 2026Article
- Comparison of dark-field chest radiography and CT for the assessment of COVID-19 pneumonia.Frontiers in radiology · 2024Article
- Dark-field chest X-ray imaging for the assessment of COVID-19-pneumonia.Communications medicine · 2022Article
- Dark-field computed tomography reaches the human scale.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- X-ray dark-field chest imaging for detection and quantification of emphysema in patients with chronic obstructive pulmonary disease: a diagnostic accuracy study.The Lancet. Digital health · 2021Article
- In-vivo X-ray dark-field computed tomography for the detection of radiation-induced lung damage in mice.Physics and imaging in radiation oncology · 2021Article
- Whole-body x-ray dark-field radiography of a human cadaver.European radiology experimental · 2021Article
- Imaging features in post-mortem x-ray dark-field chest radiographs and correlation with conventional x-ray and CT.European radiology experimental · 2019Article
- Translation from murine to human lung imaging using x-ray dark field radiography: A simulation study.PloS one · 2018Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to evaluate the feasibility of early stage imaging of acute lung inflammation in mice using grating-based X-ray dark-field imaging in vivo. Acute lung inflammation was induced in mice by orotracheal instillation of porcine pancreatic elastase. Control mice received orotracheal instillation of PBS. Mice were imaged immediately before and 1 day after the application of elastase or PBS to assess acute changes in pulmonary structure due to lung inflammation. Subsequently, 6 mice from each group were sacrificed and their lungs were lavaged and explanted for histological analysis. A further 7, 14 and 21 days later the remaining mice were imaged again. All images were acquired with a prototype grating-based small-animal scanner to generate dark-field and transmission radiographs. Lavage confirmed that mice in the experimental group had developed acute lung inflammation one day after administration of elastase. Acute lung inflammation was visible as a striking decrease in signal intensity of the pulmonary parenchyma on dark-field images at day 1. Quantitative analysis confirmed that dark-field signal intensity at day 1 was significantly lower than signal intensities measured at the remaining timepoints, confirming that acute lung inflammation can be depicted in vivo with dark-field radiography.
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