Evidence map›Paper›PMID 29391488›Full record

ArticleThe ISME journal2018

Age-associated microbiome shows the giant panda lives on hemicelluloses, not on cellulose.

Wenping Zhang, Wenbin Liu, Rong Hou, Liang Zhang, Stephan Schmitz-Esser, Huaibo Sun, Junjin Xie, Yunfei Zhang, Chengdong Wang, Lifeng Li and 5 more

Open access · hybridAbstract read
In one paragraph

Article in The ISME journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 119 citations in OpenAlex.

  1. Article
  2. Review
  3. Gut Microbiota Is Linked to Female Olfactory Preference in Giant Pandas.Animals : an open access journal from MDPI · 2026
    Article
  4. Article
  5. Giant Panda Feces-DerivedVeterinary sciences · 2026
    Article
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  11. Article
  12. Review
  13. Article
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  17. Article
  18. Review
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 5 institutions in 2 countries.

Wenping ZhangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China. zhang_zoology@163.com.
Wenbin LiuNovogene Bioinformatics Institute, Beijing, 100083, PR China.
Rong HouChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Liang ZhangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Stephan Schmitz-EsserDepartment of Animal Science, Iowa State University, Ames, 50011 IA, USA.ORCID http://orcid.org/0000-0002-1907-0709
Huaibo SunNovogene Bioinformatics Institute, Beijing, 100083, PR China.
Junjin XieChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Yunfei ZhangBiogas Institute of Ministry of Agriculture, Chengdu, 610064, Sichuan, China.
Chengdong WangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Lifeng LiNovogene Bioinformatics Institute, Beijing, 100083, PR China.
Bisong YueKey Laboratory of Bioresources and Ecoenvironment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu, 610064, Sichuan, China.
He HuangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Hairui WangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Fujun ShenChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China.
Zhihe ZhangChengdu Research Base of Giant Panda Breeding, Chengdu, 611081, Sichuan, China. zzh@panda.org.cn.
Chengdu Research Base of Giant Panda Breeding · CNNovogene Bioinformatics Institute · CNBiogas Institute of Ministry of Agriculture · CNIowa State University · USSichuan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The giant panda feeds almost exclusively on bamboo, a diet highly enriched in lignin and cellulose, but is characterized by a digestive tract similar to carnivores. It is still large unknown if and how the giant panda gut microbiota contributes to lignin and cellulose degradation. Here we show the giant pandas' gut microbiota does not significantly contribute to cellulose and lignin degradation. We found that no operational taxonomic unit had a nearest neighbor identified as a cellulolytic species or strain with a significant higher abundance in juvenile than cubs, a very low abundance of putative lignin and cellulose genes existed in part of analyzing samples but a significant higher abundance of genes involved in starch and hemicellulose degradation in juveniles than cubs. Moreover, a significant lower abundance of putative cellulolytic genes and a significant higher abundance of putative α-amylase and hemicellulase gene families were present in giant pandas than in omnivores or herbivores.

Indexed as

Gastrointestinal MicrobiomeMicrobiotaAnimalsCelluloseDietLigninPolysaccharidesUrsidaeCellulosehemicelluloseLigninPolysaccharides

Identifiers

PMID29391488
PMCPMC5931968
OpenAlexW2790162428

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.