ArticleScientific reports2018
A highly efficient murine model of experimental myopia.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Photobiology in ophthalmology: from evolutionary adaptation to translational therapeutics.Japanese journal of ophthalmology · 2026Review
- The choroidal macrophage polarization significantly influences myopia development in murine models.iScience · 2026Article
- Light and myopia: a focus on the expanding role of non-visual opsins.Eye and vision (London, England) · 2026Review
- Proteomic profiling of spontaneous myopia in guinea pigs.Frontiers in medicine · 2026Article
- Examining murine eye length asymmetry with spectral domain optical coherence tomography.Experimental eye research · 2025Article
- Polarized Light Microscopy-Based Quantification of Scleral Collagen Fiber Bundle Remodeling in the Lens-Induced Myopia Mouse Model.Life (Basel, Switzerland) · 2025Article
- Choroidal Mast Cells and Their Degranulation Are a Pivotal Trigger for Myopia Development.Investigative ophthalmology & visual science · 2025Article
- Validation of phiC31-mediated expression and functional knockout of Opn3 in the Opn3-phiC31o knock-in mouse.Eye and vision (London, England) · 2025Article
- Increased sensitivity to myopia and altered retinal ON/OFF balance in a mouse model lackingbioRxiv : the preprint server for biology · 2025Article
- Nonlinear spatial integration allows the retina to detect the sign of defocus in natural scenes.Science advances · 2025Article
- Dose-dependent myopia-suppressing effect of 4-phenlybutyric acid eye drops in a mouse myopia model under masked condition.BMC ophthalmology · 2025Article
- Antibiotics-Induced Gut Microbiome Dysbiosis Affects Susceptibility to Minus Lens-Induced Myopia in Mice.Investigative ophthalmology & visual science · 2025Article
- Comparative analysis of ocular biometrics using spectral domain optical coherence tomography with Purkinje image and optic nerve head alignments in mice.European journal of medical research · 2025Article
- Deep Spectral Library of Mice Retina for Myopia Research: Proteomics Dataset generated by SWATH and DIA-NN.Scientific data · 2024Article
- Myopic shift in female mice after ovariectomy.Scientific reports · 2024Article
- Loss of ON-Pathway Function in Mice Lacking Lrit3 Decreases Recovery From Lens-Induced Myopia.Investigative ophthalmology & visual science · 2024Article
- Insights into Myopia from Mouse Models.Annual review of vision science · 2024Review
- Early Alterations in Inner-Retina Neural and Glial Saturated Responses in Lens-Induced Myopia.Translational vision science & technology · 2024Article
- Scleral remodeling during myopia development in mice eyes: a potential role of thrombospondin-1.Molecular medicine (Cambridge, Mass.) · 2024Article
- Glucagon Increases Retinal Rod Bipolar Cell Inhibition Through a D1 Dopamine Receptor-Dependent Pathway That Is Altered After Lens-Defocus Treatment in Mice.Investigative ophthalmology & visual science · 2024Article
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the global pandemic of myopia, the precise molecular mechanism of the onset of myopia remains largely unknown. This is partially because of the lack of efficient murine myopic models that allow genetic manipulation at low cost. Here we report a highly practical and reproducible lens-induced myopia model by specially designed frames and lenses for mice. A lens power dependent myopic induction in mice was shown until minus 30 diopter lenses. The phenotype was significantly stronger than form-deprivation myopia. We presented the protocol for precise evaluations of the state of myopia, including refraction, corneal curvature and axial length using up-to-date devices. We also found that myopic mouse eyes showed decreased visual acuity on optokinetic response examination. Finally, we confirmed the anti-myopic effect of 1% atropine using this model, which showed its potential in drug screening. The strong phenotype, stable evaluation and the potential for gene manipulation utilizing the presented method in mice will accelerate the translational research of myopia.
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