ArticleScientific reports2018
Neurophysiological mechanisms of interval timing dissociate inattentive and combined ADHD subtypes.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 33 citations in OpenAlex.
- The effects of prelimbic inhibition on time-based intervention and impulsive choice.Behavioural brain research · 2027Article
- Inferring neural sources from electroencephalography: foundations and frontiers.Journal of neural engineering · 2026Review
- Movement-related cortical potentials underlying motor preparation and execution in children with attention-deficit/hyperactivity disorder.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Article
- Ambivalent bonds, positive and negative emotions, and expectations in teachers' perceptions of relationship with their students with ADHD.International journal of qualitative studies on health and well-being · 2022Article
- Time estimation and arousal responses in dopa-responsive dystonia.Scientific reports · 2022Article
- A novel approach to intra-individual performance variability in ADHD.European child & adolescent psychiatry · 2021Article
- Prospective and Retrospective Verbal Time Estimationin Children with ADHD.Advances in cognitive psychology · 2021Article
- Medial prefrontal cortex and the temporal control of action.International review of neurobiology · 2021Review
- Updates in technology-based interventions for attention deficit hyperactivity disorder.Current opinion in psychiatry · 2020Review
- Do Individuals With Obsessive-Compulsive Disorder and Obsessive-Compulsive Personality Disorder Share Similar Neural Mechanisms of Decision-Making Under Ambiguous Circumstances?Frontiers in human neuroscience · 2020Article
- Deep Learning Based on Event-Related EEG Differentiates Children with ADHD from Healthy Controls.Journal of clinical medicine · 2019Article
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Authors and funding
4 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is far from conclusive what distinguishes the inattentive (ADD) and the combined (ADHD-C) subtype of ADHD on the neuronal level. Theoretical considerations suggest that especially interval timing processes may dissociate these subtypes from each other. Combining high-density EEG recordings with source localization analyses, we examine whether there are ADHD-subtype specific modulations of neurophysiological processes subserving interval timing in matched groups of ADD (n = 16), ADHD-C (n = 16) and controls (n = 16). Patients with ADD and ADHD-C show deficits in interval timing, which was correlated with the degree of inattention in ADD patients. Compared to healthy controls, patients with ADHD-C display a somewhat weaker, yet consistent response preparation process (contingent negative variation, CNV). In patients with ADD, the early CNV is interrupted, indicating an oscillatory disruption of the interval timing process. This is associated with activations in the supplemental motor areas and the middle frontal gyrus. Patients with ADD display adequate feedback learning mechanisms (feedback-related negativity, FRN), which is not the case in patients with ADHD-C. The results suggest that altered pacemaker-accumulation processes in medial frontal structures distinguish the ADD from the ADHD-C subtype. Particularly in patients with ADD phasic interruptions of preparatory neurophysiological processes are evident, making this a possible diagnostic feature.
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