Evidence map›Paper›PMID 29391479›Full record

ArticleScientific reports2018

Expression of steroidogenic enzymes and metabolism of steroids in COS-7 cells known as non-steroidogenic cells.

Mitsuki Nozaki, Shogo Haraguchi, Takuro Miyazaki, Daichi Shigeta, Noriko Kano, Xiao-Feng Lei, Joo-Ri Kim-Kaneyama, Hiroyuki Minakata, Akira Miyazaki, Kazuyoshi Tsutsui

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Mitsuki NozakiLaboratory of Integrative Brain Sciences, Department of Biology and Center for Advanced Biomedical Sciences of Waseda University, Tokyo, 162-8480, Japan.
Shogo HaraguchiLaboratory of Integrative Brain Sciences, Department of Biology and Center for Advanced Biomedical Sciences of Waseda University, Tokyo, 162-8480, Japan. shogo.haraguchi@gmail.com.
Takuro MiyazakiDepartment of Biochemistry, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Daichi ShigetaLaboratory of Integrative Brain Sciences, Department of Biology and Center for Advanced Biomedical Sciences of Waseda University, Tokyo, 162-8480, Japan.
Noriko KanoLaboratory of Integrative Brain Sciences, Department of Biology and Center for Advanced Biomedical Sciences of Waseda University, Tokyo, 162-8480, Japan.
Xiao-Feng LeiDepartment of Biochemistry, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Joo-Ri Kim-KaneyamaDepartment of Biochemistry, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Hiroyuki MinakataSuntory Foundation for Life Sciences, Kyoto, 619-0284, Japan.
Akira MiyazakiDepartment of Biochemistry, Showa University School of Medicine, Tokyo, 142-8555, Japan.
Kazuyoshi TsutsuiLaboratory of Integrative Brain Sciences, Department of Biology and Center for Advanced Biomedical Sciences of Waseda University, Tokyo, 162-8480, Japan. k-tsutsui@waseda.jp.
Waseda University · JPShowa University · JPSuntory Foundation for Life Sciences · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COS-7 (CV-1 in Origin with SV40 genes) cells are known as non-steroidogenic cells because they are derived from kidney cells and the kidney is defined as a non-steroidogenic organ. Therefore, COS-7 cells are used for transfection experiments to analyze the actions of functional molecules including steroids. However, a preliminary study suggested that COS-7 cells metabolize [

Indexed as

Metabolic Networks and PathwaysAnimalsChlorocebus aethiopsCOS CellsCytochrome P-450 Enzyme SystemSteroid 17-alpha-HydroxylaseSteroidsCytochrome P-450 Enzyme SystemSteroid 17-alpha-HydroxylaseSteroids

Identifiers

PMID29391479
PMCPMC5794755
OpenAlexW2806057723

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.