ArticleScientific reports2018
Disrupted Resting State Network of Fibromyalgia in Theta frequency.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05099406 (Brain and Pain), which is not on this map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Brain and Pain (BaP): Understanding the Central Mechanisms of Pain to Improve Management of Patients With Refractory Chronic Pain
Who cites it
21 citing papers in PubMed, 42 citations in OpenAlex.
- Functional Magnetic Resonance Imaging Signal Variability Is Associated With Neuromodulation in Fibromyalgia.Neuromodulation : journal of the International Neuromodulation Society · 2023Trial
- Trial
- Multivariate Pattern Analysis Identifies Potential Intertrial Resting-State EEG Biomarkers in Fibromyalgia.The European journal of neuroscience · 2026Article
- Abnormal Resting-State Functional Connectivity Between the Dorsal Anterior Cingulate Cortex and the Limbic System Contributes to Pain and Emotion Regulation Impairment in Fibromyalgia Patients.International journal of rheumatic diseases · 2026Article
- Major depressive disorder in fibromyalgia: novel insights from resting-state functional connectivity analysis.The Korean journal of pain · 2025Article
- Distinct resting state neural activity in chronic pain patients who respond to transcranial electric stimulation for pain relief.Frontiers in human neuroscience · 2025Article
- Shared neural signatures in Functional Neurological Disorder and Chronic Pain: a multimodal narrative review.BMJ neurology open · 2025Article
- Can electroencephalography (EEG) identify the different dimensions of pain in fibromyalgia? A pilot study.BMC musculoskeletal disorders · 2024Article
- Persistent homology-based functional connectivity and its association with cognitive ability: Life-span study.Human brain mapping · 2023Article
- Brain structure and cortical activity changes of new daily persistent headache: multimodal evidence from MEG/sMRI.The journal of headache and pain · 2023Article
- Pain control based on oscillatory brain activity using transcranial alternating current stimulation: An integrative review.Frontiers in human neuroscience · 2023Review
- Neuroimaging Assessment of Pain.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2022Review
- Topological data analysis in biomedicine: A review.Journal of biomedical informatics · 2022Review
- CNS imaging characteristics in fibromyalgia patients with and without peripheral nerve involvement.Scientific reports · 2022Article
- The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2022Review
- Structural and functional thalamocortical connectivity study in female fibromyalgia.Scientific reports · 2021Article
- Fibromyalgia Detection Based on EEG Connectivity Patterns.Journal of clinical medicine · 2021Article
- Chronic pain-related cortical neural activity in patients with complex regional pain syndrome.IBRO neuroscience reports · 2021Article
- Elevated and Slowed EEG Oscillations in Patients with Post-Concussive Syndrome and Chronic Pain Following a Motor Vehicle Collision.Brain sciences · 2021Article
- Neurochemical Correlates of Brain Atrophy in Fibromyalgia Syndrome: A Magnetic Resonance Spectroscopy and Cortical Thickness Study.Brain sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Fibromyalgia (FM), chronic widespread pain, exhibits spontaneous pain without external stimuli and is associated with altered brain activities during resting state. To understand the topological features of brain network in FM, we employed persistent homology which is a multiple scale network modeling framework not requiring thresholding. Spontaneous magnetoencephalography (MEG) activity was recorded in 19 healthy controls (HCs) and 18 FM patients. Barcode, single linkage dendrogram and single linkage matrix were generated based on the proposed modeling framework. In theta band, the slope of decrease in the number of connected components in barcodes showed steeper in HC, suggesting FM patients had decreased global connectivity. FM patients had reduced connectivity within default mode network, between middle/inferior temporal gyrus and visual cortex. The longer pain duration was correlated with reduced connectivity between inferior temporal gyrus and visual cortex. Our findings demonstrated that the aberrant resting state network could be associated with dysfunction of sensory processing in chronic pain. The spontaneous nature of FM pain may accrue to disruption of resting state network.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.