ArticleScientific reports2018
Deep brain stimulation induces sparse distributions of locally modulated neuronal activity.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Large-scale single-neuron recording in the human cortex using an ultra-flexible electrode array.Nature communications · 2026Article
- Nonlinear dynamics and multiscale mechanisms of deep brain stimulation.Frontiers in neuroscience · 2026Review
- Model-based closed-loop control of thalamic deep brain stimulation.Frontiers in network physiology · 2024Article
- Anticipatory human subthalamic area beta-band power responses to dissociable tastes correlate with weight gain.Neurobiology of disease · 2021Article
- 7T MRI and Computational Modeling Supports a Critical Role of Lead Location in Determining Outcomes for Deep Brain Stimulation: A Case Report.Frontiers in human neuroscience · 2021Article
- Considerations Using Harmaline for a Primate Model of Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2021Article
- Frequency-dependent spike-pattern changes in motor cortex during thalamic deep brain stimulation.Journal of neurophysiology · 2020Article
- Article
- Altered Primary Motor Cortex Neuronal Activity in a Rat Model of Harmaline-Induced Tremor During Thalamic Deep Brain Stimulation.Frontiers in cellular neuroscience · 2019Article
- Innovations in electrical stimulation harness neural plasticity to restore motor function.Bioelectronics in medicine · 2018Article
- Frequency-dependent antidromic activation in thalamocortical relay neurons: effects of synaptic inputs.Journal of neural engineering · 2018Article
- Distinct Populations of Motor Thalamic Neurons Encode Action Initiation, Action Selection, and Movement Vigor.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Deep brain stimulation (DBS) therapy is a potent tool for treating a range of brain disorders. High frequency stimulation (HFS) patterns used in DBS therapy are known to modulate neuronal spike rates and patterns in the stimulated nucleus; however, the spatial distribution of these modulated responses are not well understood. Computational models suggest that HFS modulates a volume of tissue spatially concentrated around the active electrode. Here, we tested this theory by investigating modulation of spike rates and patterns in non-human primate motor thalamus while stimulating the cerebellar-receiving area of motor thalamus, the primary DBS target for treating Essential Tremor. HFS inhibited spike activity in the majority of recorded cells, but increasing stimulation amplitude also shifted the response to a greater degree of spike pattern modulation. Modulated responses in both categories exhibited a sparse and long-range spatial distribution within motor thalamus, suggesting that stimulation preferentially affects afferent and efferent axonal processes traversing near the active electrode and that the resulting modulated volume strongly depends on the local connectome of these axonal processes. Such findings have important implications for current clinical efforts building predictive computational models of DBS therapy, developing directional DBS lead technology, and formulating closed-loop DBS strategies.
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Registered trials
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