ArticleTranslational psychiatry2018
Genome-wide analysis of self-reported risk-taking behaviour and cross-disorder genetic correlations in the UK Biobank cohort.
Article in Translational psychiatry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
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Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 87 citations in OpenAlex.
- A contextual genomic perspective on physical activity and its relationship to health, well being and illness.Nature genetics · 2025Pooled it
- Genome-wide association study of early-onset bipolar I disorder in the Han Taiwanese population.Translational psychiatry · 2021Pooled it
- Genetic variation in CADM2 as a link between psychological traits and obesity.Scientific reports · 2019Pooled it
- Genome-wide association analyses of risk tolerance and risky behaviors in over 1 million individuals identify hundreds of loci and shared genetic influences.Nature genetics · 2019Pooled it
- Associations of Mechanistically Partitioned Type 2 Diabetes Polygenic Risk With Psychiatric and Related Phenotypes in UK Biobank.Biological psychiatry global open science · 2026Article
- Genome-wide association studies of lifetime and frequency of cannabis use in 131,895 individuals.Molecular psychiatry · 2026Article
- Examining whether inflammation mediates effects of genetic risk and trauma on psychopathology.BJPsych open · 2025Article
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Child maltreatment as a transdiagnostic risk factor for the externalizing dimension: a Mendelian randomization study.Molecular psychiatry · 2025Article
- Article
- Dopamine in Sports: A Narrative Review on the Genetic and Epigenetic Factors Shaping Personality and Athletic Performance.International journal of molecular sciences · 2024Review
- Integrated Pleiotropic Gene Set Unveils Comorbidity Insights across Digestive Cancers and Other Diseases.Genes · 2024Article
- Genetic associations of risk behaviours and educational achievement.Communications biology · 2024Article
- Genetic contribution to the comorbidity between attention-deficit/hyperactivity disorder and substance use disorders.Psychiatry research · 2024Article
- Article
- Dimensional and transdiagnostic phenotypes in psychiatric genome-wide association studies.Molecular psychiatry · 2023Review
- A longitudinal mediational investigation of risk pathways among cannabis use, interpersonal trauma exposure, and trauma-related distress.Psychological trauma : theory, research, practice and policy · 2023Article
- Polygenic contributions to performance on the Balloon Analogue Risk Task.Molecular psychiatry · 2023Article
- To donate or not to donate? Future healthcare professionals' opinions on biobanking of human biological material for research purposes.BMC medical ethics · 2023Article
- CADM2 is implicated in impulsive personality and numerous other traits by genome- and phenome-wide association studies in humans and mice.Translational psychiatry · 2023Article
Corrections and comments
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Authors and funding
19 authors at 5 institutions in 3 countries.
Funding
Abstract
Risk-taking behaviour is a key component of several psychiatric disorders and could influence lifestyle choices such as smoking, alcohol use, and diet. As a phenotype, risk-taking behaviour therefore fits within a Research Domain Criteria (RDoC) approach, whereby identifying genetic determinants of this trait has the potential to improve our understanding across different psychiatric disorders. Here we report a genome-wide association study in 116,255 UK Biobank participants who responded yes/no to the question "Would you consider yourself a risk taker?" Risk takers (compared with controls) were more likely to be men, smokers, and have a history of psychiatric disorder. Genetic loci associated with risk-taking behaviour were identified on chromosomes 3 (rs13084531) and 6 (rs9379971). The effects of both lead SNPs were comparable between men and women. The chromosome 3 locus highlights CADM2, previously implicated in cognitive and executive functions, but the chromosome 6 locus is challenging to interpret due to the complexity of the HLA region. Risk-taking behaviour shared significant genetic risk with schizophrenia, bipolar disorder, attention-deficit hyperactivity disorder, and post-traumatic stress disorder, as well as with smoking and total obesity. Despite being based on only a single question, this study furthers our understanding of the biology of risk-taking behaviour, a trait that has a major impact on a range of common physical and mental health disorders.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.