Evidence map›Paper›PMID 29391351›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2018

T-cell Homing Therapy for Reducing Regulatory T Cells and Preserving Effector T-cell Function in Large Solid Tumors.

Jiemiao Hu, Chuang Sun, Chantale Bernatchez, Xueqing Xia, Patrick Hwu, Gianpietro Dotti, Shulin Li

Open access · greenAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
4.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 74 citations in OpenAlex.

  1. Review
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  7. Review
  8. Multimodal cell-cell communication driving CD8Frontiers in immunology · 2025
    Review
  9. Review
  10. Review
  11. Car T Cells in Solid Tumors: Overcoming Obstacles.International journal of molecular sciences · 2024
    Review
  12. Review
  13. Article
  14. Revolutionizing cancer treatment: a comprehensive review of CAR-T cell therapy.Medical oncology (Northwood, London, England) · 2023
    Review
  15. CAR-T: What Is Next?Cancers · 2023
    Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jiemiao HuDepartment of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Chuang SunDepartment of Microbiology and Immunology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina.
Chantale BernatchezDepartment of Melanoma Medical Oncology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Xueqing XiaDepartment of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Patrick HwuDepartment of Melanoma Medical Oncology, Center for Cancer Immunology Research, The University of Texas MD Anderson Cancer Center, Houston, Texas.
Gianpietro DottiDepartment of Microbiology and Immunology, University of North Carolina, School of Medicine, Chapel Hill, North Carolina.
Shulin LiDepartment of Pediatrics-Research, The University of Texas MD Anderson Cancer Center, Houston, Texas. sli4@mdanderson.org.
The University of Texas MD Anderson Cancer Center · USUniversity of North Carolina at Chapel Hill · US

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Fabien Delerue · 1985 to 2026
$290.8M
Virology Research Program (Program 4)P30CA016086 · NCI · UNIV OF NORTH CAROLINA CHAPEL HILL · PI David Darr · 1985 to 2026
$201.5M
Gene-Product Auto-Targeting to Tumor VesselsR01CA120895 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI LI, SHULIN · 2007 to 2025
$4.8M
Tumor-Targeted Chemo-Immunotherapy for Osteosarcoma MetastasisR01CA200574 · NCI · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI LI, SHULIN, ZHANG, LIANGFANG · 2016 to 2020
$1.8M
REGULATION OF T CELL RECEPTOR EXPRESSIONF32GM018128 · NIGMS · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI LI, SHULIN · 1996 to 1997
–
NCI NIH HHS P30 CA016086NCI NIH HHS P30 CA016672NCI NIH HHS R01 CA120895NCI NIH HHS R01 CA200574NIGMS NIH HHS F32 GM018128
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Adoptive TransferAnimalsCell Line, TumorCytotoxicity, ImmunologicDisease Models, AnimalDoxorubicinHumansImmunotherapy, AdoptiveInterleukin-12Lymphocyte ActivationLymphocytes, Tumor-InfiltratingMiceNeoplasmsT-Lymphocytes, RegulatoryT-Lymphocyte SubsetsXenograft Model Antitumor AssaysDoxorubicinInterleukin-12

Identifiers

PMID29391351
PMCPMC6004229
OpenAlexW2793014800

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.