Evidence map›Paper›PMID 29391241›Full record

ArticleNeuroImage2018

Improved estimation of subject-level functional connectivity using full and partial correlation with empirical Bayes shrinkage.

Amanda F Mejia, Mary Beth Nebel, Anita D Barber, Ann S Choe, James J Pekar, Brian S Caffo, Martin A Lindquist

Abstract read
In one paragraph

Article in NeuroImage, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  7. Population-level task-evoked functional connectivity via Fourier analysis.Journal of the Royal Statistical Society. Series C, Applied statistics · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda F MejiaDepartment of Statistics, Indiana University, USA. Electronic address: afmejia@iu.edu.
Mary Beth NebelCenter for Neurodevelopmental and Imaging Research, Kennedy Krieger Institute, USA; Department of Neurology, Johns Hopkins University, USA.
Anita D BarberCenter for Psychiatric Neuroscience, Feinstein Institute for Medical Research, USA.
Ann S ChoeRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, USA.
James J PekarRussell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins University School of Medicine, USA; F.M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, USA.
Brian S CaffoDepartment of Biostatistics, Johns Hopkins University, USA.
Martin A LindquistDepartment of Biostatistics, Johns Hopkins University, USA.

Funding

'T V ASSESSMENT - MEMORY DISORDERED PATIENTS'P50AG005146 · NIA · JOHNS HOPKINS UNIVERSITY · PI TRONCOSO, JUAN · 1985 to 2019
$37.6M
Mapping the Human Connectome: Structure, Function, and HeritabilityU54MH091657 · NIMH · WASHINGTON UNIVERSITY · PI UGURBIL, KAMIL, VAN ESSEN, DAVID C · 2010 to 2014
$34.7M
TR&D 4: Algorithms for functional and anatomical brain analysisP41EB015909 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI VAN ZIJL, PETER CM · 2012 to 2020
$13.1M
Longitudinal Causal Inferencer for fMRIR01EB016061 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI LINDQUIST, MARTIN · 2013 to 2020
$2.3M
Statistical methods for large n and p problemsR01EB012547 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI CAFFO, BRIAN SCOTT · 2010 to 2016
$2.1M
Statistical Methods for Mapping Human Brain DevelopmentR01MH095836 · NIMH · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI REISS, PHILIP T · 2012 to 2016
$2.1M
Visual-Motor Development in Infants at High Risk for AutismK01MH109766 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI NEBEL, MARY BETH · 2016 to 2020
$753k
NIA NIH HHS P50 AG005146NIBIB NIH HHS P41 EB015909NIBIB NIH HHS R01 EB012547NIBIB NIH HHS R01 EB016061NIMH NIH HHS K01 MH109766NIMH NIH HHS R01 MH095836NIMH NIH HHS U54 MH091657
6 · The paper itself

Abstract

Reliability of subject-level resting-state functional connectivity (FC) is determined in part by the statistical techniques employed in its estimation. Methods that pool information across subjects to inform estimation of subject-level effects (e.g., Bayesian approaches) have been shown to enhance reliability of subject-level FC. However, fully Bayesian approaches are computationally demanding, while empirical Bayesian approaches typically rely on using repeated measures to estimate the variance components in the model. Here, we avoid the need for repeated measures by proposing a novel measurement error model for FC describing the different sources of variance and error, which we use to perform empirical Bayes shrinkage of subject-level FC towards the group average. In addition, since the traditional intra-class correlation coefficient (ICC) is inappropriate for biased estimates, we propose a new reliability measure denoted the mean squared error intra-class correlation coefficient (ICC

Indexed as

Bayes TheoremBrainConnectomeHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingNerve NetBayesian statisticsConnectomeFunctional connectivityMeasurement errorPartial correlationReliabilityResting-state fMRIShrinkage

Identifiers

PMID29391241
PMCPMC5957759

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.