Evidence map›Paper›PMID 29391183›Full record

ReviewNeuroscience and biobehavioral reviews2018

The neurobiological basis of sleep: Insights from Drosophila.

Sarah Ly, Allan I Pack, Nirinjini Naidoo

Abstract readReview
In one paragraph

Review in Neuroscience and biobehavioral reviews, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed.

  1. Trial
  2. Nutrients · 2024
    Trial
  3. iScience · 2026
    Article
  4. Invertebrate brains as diversified models for understanding sleep mechanisms and function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  5. Article
  6. Active zone plasticity couples sleep need to presynaptic hypophosphorylation.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Effects of Gallic Acid on Sleep and Circadian Rhythm in aThe Yale journal of biology and medicine · 2026
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Activity Monitoring for Analysis of Sleep inCold Spring Harbor protocols · 2024
    Article
  14. Article
  15. Effects ofAntioxidants (Basel, Switzerland) · 2023
    Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Sarah LyCenter for Sleep and Circadian Neurobiology, 125 South 31st St., Philadelphia, PA, 19104-3403, United States. Electronic address: sarahlly@pennmedicine.upenn.edu.
Allan I PackCenter for Sleep and Circadian Neurobiology, 125 South 31st St., Philadelphia, PA, 19104-3403, United States; Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, 125 South 31st St., Philadelphia, PA, 19104-3403, United States.
Nirinjini NaidooCenter for Sleep and Circadian Neurobiology, 125 South 31st St., Philadelphia, PA, 19104-3403, United States; Division of Sleep Medicine/Department of Medicine, University of Pennsylvania Perelman School of Medicine, 125 South 31st St., Philadelphia, PA, 19104-3403, United States. Electronic address: naidoo@mail.med.upenn.edu.

Funding

Training in Sleep & Sleep DisordersT32HL007953 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI David Menassah Raizen, AMY M SAWYER · 2000 to 2026
$10.6M
Mechanisms of Cellular Stress-Induced SleepR01GM123783 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI NAIDOO, NIRMALA NIRINJINI, WILLIAMS, JULIE A · 2016 to 2019
$1.3M
NHLBI NIH HHS T32 HL007953NIGMS NIH HHS R01 GM123783
6 · The paper itself

Abstract

Sleep is a biological enigma that has raised numerous questions about the inner workings of the brain. The fundamental question of why our nervous systems have evolved to require sleep remains a topic of ongoing scientific deliberation. This question is largely being addressed by research using animal models of sleep. Drosophila melanogaster, also known as the common fruit fly, exhibits a sleep state that shares common features with many other species. Drosophila sleep studies have unearthed an immense wealth of knowledge about the neuroscience of sleep. Given the breadth of findings published on Drosophila sleep, it is important to consider how all of this information might come together to generate a more holistic understanding of sleep. This review provides a comprehensive summary of the neurobiology of Drosophila sleep and explores the broader insights and implications of how sleep is regulated across species and why it is necessary for the brain.

Indexed as

SleepAnimalsBrainDrosophila melanogasterHomeostasisModels, AnimalNeurogliaNeuronsSignal TransductionDrosophila melanogasterNeurobiologySleepSleep regulation

Identifiers

PMID29391183
PMCPMC5845852

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.