ArticleThe Journal of urology2018
Intake of Trace Metals and the Risk of Incident Kidney Stones.
Article in The Journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.
- Integrative genome-wide analyses identify novel loci associated with kidney stones and provide insights into its genetic architecture.Nature communications · 2023Pooled it
- Nutrients, vitamins, probiotics and herbal products: an update of their role in urolithogenesis.Urolithiasis · 2020Pooled it
- Incidental pancytopenia in the setting of urolithiasis: severe copper deficiency without classic risk factors.BMJ case reports · 2026Article
- The Role of Copper in Struvite Formation in the Context of Infection Urinary Stones: A Journey at the Interface of Physics, Chemistry and Microbiology.Molecules (Basel, Switzerland) · 2026Article
- Research trends and frontiers on risk factors of urinary stones: a bibliometric analysis from 2010 to 2023.Renal failure · 2024Article
- Relationship between oxidative balance score and kidney stone prevalence in US adults.International urology and nephrology · 2024Article
- Association of dietary carotenoid intake with the prevalence kidney stones among the general adult population.International urology and nephrology · 2024Article
- Effect of Copper and Zinc Ions on Biochemical and Molecular Characteristics of Calcium Oxalate Renal Stones: a Controlled Clinical Study.Biological trace element research · 2024Article
- Relationship between Serum Selenium Level and Self-Reported History of Kidney Stone.Nutrients · 2023Article
- Causal relationship of genetically predicted circulating micronutrients levels with the risk of kidney stone disease: a Mendelian randomization study.Frontiers in nutrition · 2023Article
- Association between plasma cadmium and renal stone prevalence in adults in rural areas of Guangxi, China: a case-control study.BMC nephrology · 2022Article
- Analysis of Threshold Effect of Urinary Heavy Metal Elements on the High Prevalence of Nephrolithiasis in Men.Biological trace element research · 2022Article
- Dietary copper intake and the prevalence of kidney stones among adult in the United States: A propensity score matching study.Frontiers in public health · 2022Article
- Trends in the prevalence of kidney stones in the United States from 2007 to 2016.Urolithiasis · 2021Article
- Effects of Excess Manganese on the Oxidative Status, and the Expression of Inflammatory Factors and Heat Shock Proteins in Cock Kidneys.Biological trace element research · 2020Article
- Antioxidant resveratrol protects against copper oxide nanoparticle toxicity in vivo.Naunyn-Schmiedeberg's archives of pharmacology · 2018Article
- Article
Corrections and comments
- Commented on by
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
purposeThe association between the intake of trace metals and the risk of incident stones has not been longitudinally investigated. MATERIALS AND
methodsWe performed a prospective analysis of 193,551 participants in the Health Professionals Follow-up Study, and the Nurses' Health Study I and II. During a followup of 3,316,580 person-years there was a total of 6,576 incident stones. We used multivariate regression models to identify associations of the intake of zinc, iron, copper and manganese with the risk of stones. In a subset of participants with 24-hour urine collections we examined the association between the intake of trace metals and urine composition.
resultsAfter multivariate adjustment total and dietary intakes of zinc and iron were not significantly associated with incident stones. A higher intake of manganese was associated with a lower risk of stones. The pooled HR of the highest quintile of total manganese intake compared with the lowest intake was 0.82 (95% CI 0.68-0.98, p = 0.02). Total but not dietary copper intake was marginally associated with a higher risk of stones (pooled HR 1.14, 95% CI 1.02-1.28, p = 0.01). There were no statistically significant associations of the total intake of manganese and copper with urinary supersaturation.
conclusionsZinc and iron intake was not associated with a risk of stones. Copper intake may be associated with a higher risk in some individuals. Higher total manganese intake was associated with a lower risk of stones but not with traditional 24-hour urinary composite markers of stone risk. Further research is needed to elucidate the mechanisms by which manganese may reduce kidney stone formation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.