ArticleBMC complementary and alternative medicine2018
Anti-inflammatory activities of Guang-Pheretima extract in lipopolysaccharide-stimulated RAW 264.7 murine macrophages.
Article in BMC complementary and alternative medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
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- Extract ofPharmaceutical biology · 2022Article
- Development of a Sericin Hydrogel to Deliver Anthocyanins from Purple Waxy Corn Cob (Pharmaceutics · 2022Article
- α‑rhamnrtin‑3‑α‑rhamnoside exerts anti‑inflammatory effects on lipopolysaccharide‑stimulated RAW264.7 cells by abrogating NF‑κB and activating the Nrf2 signaling pathway.Molecular medicine reports · 2021Article
- Protective Effect of Brassica napus L. Hydrosols against Inflammation Response in RAW 264.7 Cells.Chinese journal of integrative medicine · 2021Article
- An Integrated Analysis of Network Pharmacology and Experimental Validation to Reveal the Mechanism of Chinese Medicine Formula Naotaifang in Treating Cerebral Ischemia-Reperfusion Injury.Drug design, development and therapy · 2021Article
- Systematic Review: Guideline-Based Approach for the Management of Asthma and Subtypes via Chinese Medicine.Evidence-based complementary and alternative medicine : eCAM · 2021Review
- Antioxidant, Anti-inflammatory Activities and Polyphenol Profile of Rhamnus prinoides.Pharmaceuticals (Basel, Switzerland) · 2020Article
- Antioxidant and Anti-Inflammatory Activities of the Crude Extracts ofAntioxidants (Basel, Switzerland) · 2019Article
- Specific DNA identification of Pheretima in the Naoxintong capsule.Chinese medicine · 2019Article
- Anti-inflammation effects of 8-oxo-9-octadecenoic acid isolated fromEXCLI journal · 2018Article
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7 authors.
Funding
Abstract
backgroundGuang-Pheretima, which is originated from Pheretima aspergillum, has been documented in academic Chinese herbal studies for nearly 2000 years for its prominent treating effects of various inflammatory diseases such as asthma, cough and fever. However, the anti-inflammatory activity and mechanism of Guang-Pheretima has been rarely reported. Hence, we investigated the inhibitory effect and the underlying mechanism of Guang-Pheretima aqueous extracts on inflammatory response in RAW 264.7 cells.
methodRAW 264.7 macrophages were pretreated with various concentrations of Guang-Pheretima decoction (GPD) or protein-free Guang-Pheretima decoction (PF-GPD) and subsequently stimulated with lipopolysaccharide (LPS) to trigger the inflammatory response. Productions of nitric oxide (NO) were determined by Griess reaction, and prostaglandin E
resultsGPD of the experimental concentrations showed no anti-inflammatory activity. In contrast, PF-GPD at concentrations of 40-320 μg/mL significantly inhibited NF-κB activation and reduced the production of inflammatory mediators, such as NO, PGE
conclusionThese results demonstrate the excellent anti-inflammatory properties of PF-GPD, and suggest that Guang-Pheretima may be used to treat and prevent certain inflammatory diseases.
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